Updated analysis on polypharmacy and mortality from the ESTHER study

  • Ben Schöttker
  • Dana Clarissa Muhlack
  • Liesa Katharina Hoppe
  • Bernd Holleczek
  • Hermann Brenner
Letter to the Editor


Compliance with ethical standards

The ESTHER study was approved by the ethics committees of the Medical Faculty of the University of Heidelberg and the Medical Association of Saarland and is being conducted in accordance with the declaration of Helsinki.

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Schöttker B, Saum KU, Muhlack DC, Hoppe LK, Holleczek B, Brenner H (2017) Polypharmacy and mortality: new insights from a large cohort of older adults by detection of effect modification by multi-morbidity and comprehensive correction of confounding by indication. Eur J Clin Pharmacol 73:1041–1048CrossRefPubMedGoogle Scholar
  2. 2.
    Nathan A, Goodyer L, Lovejoy A, Rashid A (1999) ‘Brown bag’ medication reviews as a means of optimizing patients’ use of medication and of identifying potential clinical problems. Fam Pract 16:278–282CrossRefPubMedGoogle Scholar
  3. 3.
    Hudon C, Fortin M, Vanasse A (2005) Cumulative Illness Rating Scale was a reliable and valid index in a family practice context. J Clin Epidemiol 58:603–608CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Clinical Epidemiology and Aging ResearchGerman Cancer Research CenterHeidelbergGermany
  2. 2.Network Aging ResearchUniversity of HeidelbergHeidelbergGermany
  3. 3.Institute of Health Care and Social SciencesFOM UniversityEssenGermany
  4. 4.Saarland Cancer RegistrySaarbrückenGermany

Personalised recommendations