Paroxetine ameliorates whole-body allodynia
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Allodynia is one of the features of neuropathic pain, but its therapy is still insufficient . Among the pathological mechanisms of neuropathic pain, the involvement of microglia has been well investigated. Especially, the upregulation of the P2X4 receptor, an ionotropic ATP receptor, in the microglia is a key molecular mechanism . Paroxetine has a remarkable antagonistic potential for the P2X4 receptor . Although the reported IC50 values for inhibition of the receptor function are similar between paroxetine (1.87 μM)  and duloxetine (1.59 μM) , paroxetine causes a slightly more complete attenuation of the P2X4 receptor function (to approximately 4% of control response of the receptor) than duloxetine (to about 9%)  that is one of the recommended drugs for the treatment of neuropathic pain. Indeed, paroxetine relieves allodynia in rodent models . However, a recent therapeutic strategy for neuropathic pain does not mention such an analgesic effect of paroxetine ....
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