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Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials

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Abstract

Purpose

To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness).

Methods

Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-DL-leucine, Acetyl-leucine. Trial selection: randomised controlled trials (RCTs) comparing acetylleucine against placebo.

Results

Up until 2018, no RCTs have been published on the efficacy of acetylleucine in vertigo/dizziness.

Conclusion

There is no solid evidence of the efficacy of acetylleucine in vertigo/dizziness. Given its frequent prescription and the cost generated for the French social security system, high-quality randomised trials should be carried out to assess its efficacy.

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Author information

Authors and Affiliations

  1. Department of General Medicine, University of Poitiers, 6 rue de la Milétrie, TSA 51115, 86073, Poitiers Cedex 9, France

    Paul Vanderkam & Clara Blanchard

  2. Clinical Research Unit, Henri Laborit Hospital, 370 av. Jacques cœur, CS 10587, 86021, Poitiers, France

    Paul Vanderkam

  3. CHU Rennes, Inserm, CIC 1414 (Clinical Center of Investigation, Rennes), Univ Rennes, F-35000, Rennes, France

    Florian Naudet

  4. Department of General Medicine, University of Tours, 10 boulevard Tonnelé, BP 3223, 37032, Tours Cedex 1, France

    Denis Pouchain

  5. Department of General Medicine and UPU ACCePPT, University of Auvergne Clermont-Ferrand Cedex 1, France28 place Henri Dunant, BP 38, 63001, Clermont-Ferrand Cedex 1, France

    Helene Vaillant Roussel

  6. Clinical Pharmacology and Awareness Department, University Hospital of Poitiers, 2 rue de la Milétrie, BP 577, 86021, Poitiers Cedex, France

    Marie Christine Perault-Pochat

  7. CNRS 3557, CIC-P 1402 and Clinical Research Unit, Henri Laborit Hospital, 370 av. Jacques cœur, CS 10587, 86021, Poitiers, France

    Nematollah Jaafari

  8. University College of General Medicine and UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Claude-Bernard Lyon 1 University, CNRS, Lyon, 69622, France

    Rémy Boussageon

Authors
  1. Paul Vanderkam
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Contributions

Paul Vanderkam performed the research, analysed the data and wrote the paper.

Clara Blanchard contributed to the writing of the paper and the data analysis.

Florian Naudet contributed to the writing of the paper.

Denis Pouchain contributed to the writing of the paper.

Marie-Christine Perrault-Pochat contributed to the writing of the paper.

Hélène Vaillant-Roussel contributed to the writing of the paper.

Nematollah Jaafari contributed to the writing of the paper.

Remy Boussageon conceived the study and analysed the data.

Corresponding author

Correspondence to Paul Vanderkam.

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Vanderkam, P., Blanchard, C., Naudet, F. et al. Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials. Eur J Clin Pharmacol 75, 603–607 (2019). https://doi.org/10.1007/s00228-018-02617-6

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  • DOI: https://doi.org/10.1007/s00228-018-02617-6

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