References
Schrier RW, Gross P, Gheorghiade M, Berl T, Verbalis JG, Czerwiec FS et al (2006) Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med 355(20):2099–2112
Salahudeen AK, Ali N, George M, Lahoti A, Palla S (2014) Tolvaptan in hospitalized cancer patients with hyponatremia: a double-blind, randomized, placebo-controlled clinical trial on efficacy and safety. Cancer 120(5):744–751
Berl T, Quittnat-Pelletier F, Verbalis JG, Schrier RW, Bichet DG, Ouyang J et al (2010) Oral tolvaptan is safe and effective in chronic hyponatremia. J Am Soc Nephrol 21(4):705–712
Acknowledgements
We thank Dr. Chris Boot (Newcastle upon Tyne) for the measurement of plasma copeptin.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
Professor Chris Thompson has received honoraria for lectures from Otsuka.
Dr. Aoife Garrahy, Dr. Anne Marie Hannon, Dr. Zia-Ul-Hussnain, and Professor David Williams have no potential conflicts of interest.
Electronic supplementary material
ESM 1
(DOCX 46 kb)
Rights and permissions
About this article
Cite this article
Garrahy, A., Hannon, A.M., Zia-Ul-Hussnain, H.M. et al. Secondary resistance to tolvaptan in two patients with SIAD due to small cell lung cancer. Eur J Clin Pharmacol 74, 245–246 (2018). https://doi.org/10.1007/s00228-017-2363-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00228-017-2363-7