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Response: Amiodarone-induced thyroid dysfunction and a perturbed N-desethyl-amiodarone to amiodarone ratio; could a drug-induced toxicity be regulating exposure to the offending agent?

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References

  1. Yamato M, Wada K, Fujimoto M, Hosomi K, Hayashi T, Oita A, Takada M (2017) Association between N-desethylamiodarone/amiodarone ratio and amiodarone-induced thyroid dysfunction. Eur J Clin Pharmacol 73(3):289–296. doi:10.1007/s00228-017-2195-5

    Article  CAS  PubMed  Google Scholar 

  2. Berta E, Harangi M, Zsiros N, Nagy EV, Paragh G, Bodor M (2014) Effect of thyroid hormone status and concomitant medication on statin induced adverse effects in hyperlipidemic patients. Pharmazie 69(6):420–423

    CAS  PubMed  Google Scholar 

  3. Sarlis NJ, Gourgiotis L (2005) Hormonal effects on drug metabolism through the CYP system: perspectives on their potential significance in the era of pharmacogenomics. Curr Drug Targets Immune Endocr Metabol Disord 5(4):439–448

    Article  CAS  PubMed  Google Scholar 

  4. Istrate MA, Nussler AK, Eichelbaum M, Burk O (2010) Regulation of CYP3A4 by pregnane X receptor: the role of nuclear receptors competing for response element binding. Biochem Biophys Res Commun 393(4):688–693. doi:10.1016/j.bbrc.2010.02.058

    Article  CAS  PubMed  Google Scholar 

  5. Park YJ, Lee EK, Lee YK, Park DJ, Jang HC, Moore DD (2012) Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. Toxicol Appl Pharmacol 263(2):131–137. doi:10.1016/j.taap.2012.03.017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Mitsutaka Takada.

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Takada, M., Yamato, M., Wada, K. et al. Response: Amiodarone-induced thyroid dysfunction and a perturbed N-desethyl-amiodarone to amiodarone ratio; could a drug-induced toxicity be regulating exposure to the offending agent?. Eur J Clin Pharmacol 73, 1053–1054 (2017). https://doi.org/10.1007/s00228-017-2262-y

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  • DOI: https://doi.org/10.1007/s00228-017-2262-y

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