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Respiratory depression related to multiple drug–drug interactions precipitated by a fluconazole loading dose in a patient treated with oxycodone

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Authors’ contributions

B C first collected the patient data, described the case, and reported it to the appropriate local pharmacovigilance unit. B C and JY M conceived the idea of publishing the case. B D, G B, and JY M cared for the patient and reviewed the case. MC G performed the genotyping. B C and M T drafted the manuscript. All authors contributed to the scientific discussion and to the final preparation of the manuscript.

According to French law, informed written consent was obtained from the patient for genotyping. This case has been reported to the National Health Authorities “French Pharmacovigilance Database” (registered as number LY20160971).

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Authors and Affiliations

  1. Pharmacie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103, Grande Rue de la Croix-Rousse, 69317, Lyon Cedex 04, France

    Bruno Charpiat & Michel Tod

  2. Pharmacie, Hôpital de la Croix-Rousse, 103 Grande rue de la Croix-Rousse, Groupement Hospitalier Nord, 69004, Lyon, France

    Bruno Charpiat

  3. Service de Chirurgie Générale, Digestive et de Transplantation Hépatique, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103, Grande Rue de la Croix-Rousse, 69317, Lyon Cedex 04, France

    Benjamin Darnis & Jean-Yves Mabrut

  4. Service d’Anesthésie et de Réanimation, Hôpital de la Croix-Rousse, Groupement Hospitalier Nord, Hospices Civils de Lyon, 103, grande rue de la Croix-Rousse, 69317, Lyon Cedex 04, France

    Guillaume Boulay

  5. Unité de Pharmacologie, Hôpital Edouard Herriot, Hospices Civils de Lyon, 5 Place d’Arsonval, 69003, Lyon, France

    Marie-Claude Gagnieu

Authors
  1. Bruno Charpiat
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  2. Michel Tod
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  3. Benjamin Darnis
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  4. Guillaume Boulay
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  5. Marie-Claude Gagnieu
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  6. Jean-Yves Mabrut
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Corresponding author

Correspondence to Bruno Charpiat.

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Charpiat, B., Tod, M., Darnis, B. et al. Respiratory depression related to multiple drug–drug interactions precipitated by a fluconazole loading dose in a patient treated with oxycodone. Eur J Clin Pharmacol 73, 787–788 (2017). https://doi.org/10.1007/s00228-017-2215-5

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  • DOI: https://doi.org/10.1007/s00228-017-2215-5

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