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Effect of magnesium supplementation on lipid profile: a systematic review and meta-analysis of randomized controlled trials

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Abstract

Purpose

We performed a meta-analysis of randomized controlled trials (RCTs) in order to evaluate the effect of oral magnesium supplementation on lipid profile of both diabetic and non-diabetic individuals.

Methods

PubMed-Medline, SCOPUS, Web of Science, and Google Scholar databases were searched (from inception to February 23, 2016) to identify RCTs evaluating the effect of magnesium on lipid concentrations. A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations.

Results

Magnesium treatment was not found to significantly affect plasma concentrations of any of the lipid indices including total cholesterol (WMD 0.03 mmol/L, 95% CI −0.11, 0.16, p = 0.671), LDL-C (WMD −0.01 mmol/L, 95% CI −0.13, 0.11, p = 0.903), HDL-C (WMD 0.03 mmol/L, 95% CI −0.003, 0.06, p = 0.076), and triglycerides concentrations (WMD −0.10 mmol/L, 95% CI −0.25, 0.04, p = 0.149). In a subgroup analysis comparing studies with and without diabetes, no difference was observed between subgroups in terms of changes in plasma total cholesterol (p = 0.924), LDL-C (p = 0.161), HDL-C (p = 0.822), and triglyceride (p = 0.162) concentrations.

Conclusions

Results of the present meta-analysis indicated that magnesium supplementation showed no significant effects on the lipid profile of either diabetic or non-diabetic individuals.

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Contributions of authors statement

LESM conceptualized and designed the study, drafted the initial manuscript, and approved the final manuscript as submitted. MSM designed the study, drafted the initial manuscript, critically reviewed the manuscript, and approved the final manuscript as submitted. AS carried out the statistical analyses and interpretation of data, critically reviewed the manuscript, and approved the final manuscript as submitted. MRM drafted the initial manuscript, critically reviewed the manuscript, and approved the final manuscript as submitted. FGR conceptualized and designed the study, drafted the initial manuscript, critically reviewed the manuscript, and approved the final manuscript as submitted

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Authors and Affiliations

  1. Biomedical Research Unit, Mexican Social Security Institute, Canoas 100, Col. Los Angeles, 34067, Durango, Mexico

    Luis E. Simental-Mendía, Martha Rodríguez-Morán & Fernando Guerrero-Romero

  2. Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Autonomous University of Nuevo León, Monterrey, NL, Mexico

    Mario Simental-Mendía

  3. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  4. Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia

    Amirhossein Sahebkar

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  1. Luis E. Simental-Mendía
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  4. Martha Rodríguez-Morán
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Corresponding author

Correspondence to Fernando Guerrero-Romero.

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Electronic supplementary material

Figure S1

Random-effects meta-regression plots of the association between mean changes in plasma concentrations of lipids and dose of magnesium. (TIFF 250 kb)

High resolution image (GIF 99 kb)

Figure S2

Random-effects meta-regression plots of the association between mean changes in plasma concentrations of lipids and duration of treatment with magnesium. (TIFF 247 kb)

High resolution image (GIF 96 kb)

Figure S3

Random-effects meta-regression plots of the association between mean changes in plasma concentrations of lipids and baseline lipid concentrations. (TIFF 262 kb)

High resolution image (GIF 103 kb)

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Simental-Mendía, L.E., Simental-Mendía, M., Sahebkar, A. et al. Effect of magnesium supplementation on lipid profile: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Pharmacol 73, 525–536 (2017). https://doi.org/10.1007/s00228-017-2212-8

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  • DOI: https://doi.org/10.1007/s00228-017-2212-8

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