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Table 2 Division of AIDS table for grading the severity of adult and paediatric adverse events version 1.0, December, 2004; clarification August 2009

From: Safety of zidovudine/lamivudine scored tablets in children with HIV infection in Europe and Thailand

Parameter Grade 1 mild Grade 2 moderate Grade 3 severe Grade 4 potentially life threatening
Absolute neutrophil count
 Adult and paediatric >7 days 1000–1300/mm3
1.000 × 109–1.300 × 109/L
750–999/mm3
0.750 × 109–0.999 × 109/L
500–749/mm3
0.500 × 109–0.749 × 109/L
<500/mm3
<0.500 × 109/L
Alanine aminotransferase (ALT) 1.25–2.5 × ULN 2.6–5.0 × ULN 5.1–10.0 × ULN >10.0 × ULN
Aspartate aminotransferase (AST) 1.25–2.5 × ULN 2.6–5.0 × ULN 5.1–10.0 × ULN >10.0 × ULN
Bilirubin (total)
 Adult and paediatric >14 days 1.1–1.5 × ULN 1.6–2.5 × ULN 2.6–5.0 × ULN >5.0 × ULN
Haemoglobin
 Adult and paediatric ≥57 days (HIV positive only) 8.5–10.0 g/dL
5.24–6.23 mmol/L
7.5–8.4 g/dL
4.62–5.23 mmol/L
6.50–7.4 g/dL
4.03–4.61 mmol/L
<6.5 g/dL
<4.03 mmol/L
Platelets, decreased 100,000–124,999/mm3
100.000 × 109–124.999 × 109/L
50,000–99,999/mm3
50.000 × 109–99.999 × 109/L
25,000–49,999/mm3
25.000 × 109–49.999 × 109/L
<25,000/mm3
<25.000 × 109/L
White blood cells, decreased 2000–2500/mm3
2.000 × 109–2.500 × 109/L
1500–1999/mm3
1.500 × 109–1.999 × 109/L
1000–1499/mm3
1.000 × 109–1.499 × 109/L
<1000/mm3
<1.000 × 109/L
  1. (Reproduced from http://rsc.tech-res.com/docs/default-source/safety/table_for_grading_severity_of_adult_pediatric_adverse_events.pdf)