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Severe liver injury due to a homemade flower pollen preparation in a patient with high CYP3A enzyme activity: a case report

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References

  1. Wu CH, Wang CC, Kennedy J (2011) Changes in herb and dietary supplement use in the U.S. adult population: a comparison of the 2002 and 2007 National Health Interview Surveys. Clin Ther 33:1749–1758

    Article  PubMed  Google Scholar 

  2. Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, United States Drug Induced Liver Injury Network et al (2015) Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study. Gastroenterology 148:1340–1352

    Article  PubMed  Google Scholar 

  3. Zhou SF, Xue CC, Yu XQ, Wang G (2007) Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. Curr Drug Metab 8:526–553

    Article  CAS  PubMed  Google Scholar 

  4. Bosilkovska M, Samer CF, Déglon J, Rebsamen M, Staub C, Dayer P et al (2014) Geneva cocktail for cytochrome P450 and P-glycoprotein activity assessment using dried blood spots. Clin Pharmacol Ther 96:349–359

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zanger UM, Schwab M (2013) Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 138:103–141

    Article  CAS  PubMed  Google Scholar 

  6. EFSA Panel on Contaminant in the Food Chain (CONTAM) (2011) Scientific opinion on pyrrolizidine alkaloids in food and feed. EFSA J 9:2406

  7. Maria V, Victorino R (1997) Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 26:664–669

    Article  CAS  PubMed  Google Scholar 

  8. Danan G, Benichou C (1993) Causality assessment of adverse reactions to drugs—I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 46:1323–1330

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, CH-1211, Geneva, Switzerland

    Victoria Rollason & Monica Escher

  2. Division of Gastroenterology and Hepatology, Geneva University Hospitals, CH-1211, Geneva, Switzerland

    Laurent Spahr

Authors
  1. Victoria Rollason
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  2. Laurent Spahr
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  3. Monica Escher
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Correspondence to Victoria Rollason.

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Rollason, V., Spahr, L. & Escher, M. Severe liver injury due to a homemade flower pollen preparation in a patient with high CYP3A enzyme activity: a case report. Eur J Clin Pharmacol 72, 507–508 (2016). https://doi.org/10.1007/s00228-015-1986-9

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  • DOI: https://doi.org/10.1007/s00228-015-1986-9

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