Skip to main content
SpringerLink
Log in

Gastric emptying and acetaminophen: lessons learnt from the several co-administered drugs on the experimental design

  • Letter to the Editors
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Prescott LF (1980) Kinetics and metabolism of paracetamol and phenacetin. Br J Clin Pharmacol 10(Suppl 2):291S–298S

    Article  PubMed Central  PubMed  Google Scholar 

  2. Clements JA, Heading RC, Nimmo WS, Prescott LF (1978) Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther 24:420–431

    Article  CAS  PubMed  Google Scholar 

  3. Petring OU, Flachs H (1990) Inter- and intrasubject variability of gastric emptying in healthy volunteers measured by scintigraphy and paracetamol absorption. Br J Clin Pharmacol 29:703–708

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Yuan CS, Foss JF, O’Connor M, Roizen MF, Moss J (1998) Effects of low-dose morphine on gastric emptying in healthy volunteers. J Clin Pharmacol 38:1017–1020

    Article  CAS  PubMed  Google Scholar 

  5. Ayalasomayajula S, Meyers D, Koo P, Salunke A, Majumdar T, Rebello S, Sunkara G, Chen J (2015) Assessment of pharmacokinetic drug-drug interaction between pradigastat and acetaminophen in healthy subjects. Eur J Clin Pharmacol 71:425–432

    Article  CAS  PubMed  Google Scholar 

  6. Kellmeyer TA, Kesty NC, Wang Y, Frias JP, Fineman MS (2007) Pharmacokinetics of an oral drug (acetaminophen) administered at various times relative to subcutaneous injection of pramlintide in subjects with type 2 diabetes. J Clin Pharmacol 47:798–805

    Article  CAS  PubMed  Google Scholar 

  7. Blase E, Taylor K, Gao HY, Wintle M, Fineman M (2005) Pharmacokinetics of an oral drug (acetaminophen) administered at various times in relation to subcutaneous injection of exenatide (exendin-4) in healthy subjects. J Clin Pharmacol 45:570–577

    Article  CAS  PubMed  Google Scholar 

  8. Renner B, Clarke G, Grattan T, Beisel A, Mueller C, Werner U, Kobal G, Brune K (2007) Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen. J Clin Pharmacol 47:715–726

    Article  CAS  PubMed  Google Scholar 

  9. Samsom M, Szarka LA, Camilleri M, Vella A, Zinsmeister AR, Rizza RA (2000) Pramlintide, an amylin analog, selectively delays gastric emptying: potential role of gastric emptying. Am J Physiol Gastrointest Liver Physiol 278:G946–G951

    CAS  PubMed  Google Scholar 

  10. Naslund E, Bogefors J, Skogar S, Grybäck P, Jacobsson H, Holst JJ, Hellström PM (1999) GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol 277:R910–R916

    CAS  PubMed  Google Scholar 

  11. Biaggioni I, Paul S, Puckett A, Arzubiaga C (1991) Caffeine and theophylline as adenosine receptor antagonists in humans. J Pharmacol Exp Ther 258:588–593

    CAS  PubMed  Google Scholar 

  12. Nehlig A, Daval JL, Debry G (1992) Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev 17:139–170

    Article  CAS  PubMed  Google Scholar 

  13. Lee CA, Lillibridge JH, Nelson SD, Slattery JT (1996) Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation. J Pharmacol Exp Ther 277:287–291

    CAS  PubMed  Google Scholar 

  14. Podilsky G, Berger-Gryllaki M, Testa B, Buclin T, Roulet M, Pannatier A (2009) The bioavailability of bromazepam, omeprazole and paracetamol given by nasogastric feeding tube. Eur J Clin Pharmacol 65:435–442

    Article  CAS  PubMed  Google Scholar 

  15. Srinivas NR (2015) Acetaminophen absorption kinetics in altered gastric emptying: Establishing a relevant pharmacokinetic surrogate using published data. J Pain Palliat Care Pharmacother 29:115–9

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Suramus Bio, Drug Development, J.P. Nagar, I Phase, Bangalore, 560078, India

    Nuggehally R. Srinivas

Authors
  1. Nuggehally R. Srinivas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nuggehally R. Srinivas.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Srinivas, N.R. Gastric emptying and acetaminophen: lessons learnt from the several co-administered drugs on the experimental design. Eur J Clin Pharmacol 72, 369–371 (2016). https://doi.org/10.1007/s00228-015-1937-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00228-015-1937-5

Keywords

Search

Navigation