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Effect of hepatitis B and C clearance on atazanavir exposure

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References

  1. Wang XZ, Li D, Tao QM, Lin N, Chen ZX (2006) A novel hepatitis B virus X-interactive protein: cytochrome C oxidase III. J Gastroenterol Hepatol 21:711–715

    Article  CAS  PubMed  Google Scholar 

  2. Niu Y, Wu Z, Shen Q, Song J, Luo Q, You H, et al (2013) Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis. Dig Liver Dis 45:1041–1048

    Article  CAS  PubMed  Google Scholar 

  3. Kirby GM, Batist G, Alpert L, Lamoureux E, Cameron RG, Alaoui-Jamali MA (1996) Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis. Toxicol Pathol 24:458–467

    Article  CAS  PubMed  Google Scholar 

  4. Morcos PN, Moreira SA, Brennan BJ, Blotner S, Shulman NS, Smith PF (2013) Influence of chronic hepatitis C infection on cytochrome P450 3A4 activity using midazolam as an in vivo probe substrate. Eur J Clin Pharmacol 69:1777–1784

    Article  CAS  PubMed  Google Scholar 

  5. Gervasoni C, Meraviglia P, Minisci D, Ferraris L, Riva A, Landonio S, et al (2015) Metabolic and kidney disorders correlate with high atazanavir concentrations in HIV-infected patients: is it time to revise atazanavir dosages? PLoS One 10:e0123670

    Article  PubMed Central  PubMed  Google Scholar 

  6. Pageaux GP, le Bricquir Y, Berthou F, Bressot N, Picot MC, Blanc F, Michel H, Larrey D (1998) Effects of interferon-alpha on cytochrome P-450 isoforms 1A2 and 3A activities in patients with chronic hepatitis C. Eur J Gastroenterol Hepatol 10(6):491–495

    Article  CAS  PubMed  Google Scholar 

  7. Kiang TK, Wilby KJ, Ensom MH (2013) Telaprevir: clinical pharmacokinetics, pharmacodynamics, and drug-drug interactions. Clin Pharmacokinet 52:487–510

    Article  CAS  PubMed  Google Scholar 

  8. Milazzo L, Cattaneo D, Calvi E, Gervasoni C, Mazzali C, Ronzi P, et al (2015) Pharmacokinetic interactions between telaprevir and antiretroviral drugs in HIV/HCV-coinfected patients with advanced liver fibrosis and prior HCV non-responders. Int J Antimicrob Agents 45:545–549

    Article  CAS  PubMed  Google Scholar 

  9. Bentué-Ferrer D, Arvieux C, Tribut O, Ruffault A, Bellissant E (2009) Clinical pharmacology, efficacy and safety of atazanavir: a review. Expert Opin Drug Metab Toxicol 5:1455–1468

    Article  PubMed  Google Scholar 

  10. de Lastours V, Ferrari Rafael De Silva E, Daudon M, Porcher R, Loze B, Sauvageon H, et al (2013) High levels of atazanavir and darunavir in urine and crystalluria in asymptomatic patients. J Antimicrob Chemother 68:1850–1856

    Article  PubMed  Google Scholar 

  11. Van den Eynde E, Ferrer E, Podzamczer D (2014) Acute renal failure and liver toxicity in an HIV/hepatitis C coinfected patient receiving telaprevir and boosted atazanavir. AIDS 28:1538–1539

    Article  PubMed  Google Scholar 

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Funding

This study was carried out as part of our routine work.

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The authors declare that they have no competing interests.

Compliance with ethical standards

This is a retrospective observation describing a case; the patient provided written consent for the case report.

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Correspondence to Cristina Gervasoni.

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Gervasoni, C., Cattaneo, D., Micheli, V. et al. Effect of hepatitis B and C clearance on atazanavir exposure. Eur J Clin Pharmacol 71, 1409–1411 (2015). https://doi.org/10.1007/s00228-015-1926-8

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  • DOI: https://doi.org/10.1007/s00228-015-1926-8

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