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Genotypes at rs2844682 and rs3909184 have no clinical value in identifying HLA-B*15:02 carriers

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References

  1. Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT (2004) Medical genetics: a marker for Stevens-Johnson syndrome. Nature 428:486. doi:10.1038/428486a

    Article  CAS  PubMed  Google Scholar 

  2. Chen P, Lin JJ, Lu CS, Ong CT, Hsieh PF, Yang CC, Tai CT, Wu SL, Lu CH, Hsu YC, Yu HY, Ro LS, Lu CT, Chu CC, Tsai JJ, Su YH, Lan SH, Sung SF, Lin SY, Chuang HP, Huang LC, Chen YJ, Tsai PJ, Liao HT, Lin YH, Chen CH, Chung WH, Hung SI, Wu JY, Chang CF, Chen L, Chen YT, Shen CY, for the Taiwan SJS Consortium (2011) Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med 364:1126–1133. doi:10.1056/NEJMoa1009717

    Article  CAS  PubMed  Google Scholar 

  3. Grover S, Kukreti R (2014) HLA alleles and hypersensitivity to carbamazepine: an updated systematic review with meta-analysis. Pharmacogenet Genomics 24:94–112. doi:10.1097/FPC.0000000000000021

    Article  CAS  PubMed  Google Scholar 

  4. Bloch KM, Sills GJ, Pirmohamed M, Alfirevic A (2014) Pharmacogenetics of antiepileptic drug-induced hypersensitivity. Pharmacogenomics 15:857–868. doi:10.2217/pgs.14.65

    Article  CAS  PubMed  Google Scholar 

  5. Caudle KE, Rettie AE, Whirl-Carrillo M, Smith LH, Mintzer S, Lee MT, Klein TE, Callaghan JT (2014) Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C9 and HLA-B genotypes and phenytoin dosing. Clin Pharmacol Ther 96:542–548. doi:10.1038/clpt.2014.159

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Tegretol® and Tegretol®-XR prescribing information: FDA approved labeling text dated 9/12/2014. http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/016608s099,018281s047,018927s040,020234s030lbl.pdf. Accessed 14 April 2015

  7. International HapMap Consortium (2003) The International HapMap Project. Nature 426:789–796. doi:10.1038/nature02168

    Article  Google Scholar 

  8. de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD (2006) A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 38:1166–1172. doi:10.1038/ng1885

    Article  PubMed Central  PubMed  Google Scholar 

  9. Thorn CF, Leckband SG, Kelsoe J, Leeder JS, Muller DJ, Klein TE, Altman RB (2011) PharmGKB summary: carbamazepine pathway. Pharmacogenet Genomics 21:906–910. doi:10.1097/FPC.0b013e328348c6f2

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Zhang W, Roederer MW, Chen WQ, Fan L, Zhou HH (2012) Pharmacogenetics of drugs withdrawn from the market. Pharmacogenomics 13:223–231. doi:10.2217/pgs.11.137

    Article  CAS  PubMed  Google Scholar 

  11. Drozda K, Muller DJ, Bishop JR (2014) Pharmacogenomic testing for neuropsychiatric drugs: current status of drug labeling, guidelines for using genetic information, and test options. Pharmacotherapy 34:166–184. doi:10.1002/phar.1398

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Salloum NC, McCarthy MJ, Leckband SG, Kelsoe JR (2014) Towards the clinical implementation of pharmacogenetics in bipolar disorder. BMC Med 12:90. doi:10.1186/1741-7015-12-90

    Article  PubMed Central  PubMed  Google Scholar 

  13. Kim JY, Cheong HS, Park TJ, Shin HJ, Seo DW, Na HS, Chung MW, Shin HD (2014) Screening for 392 polymorphisms in 141 pharmacogenes. Biomed Rep 2:463–476. doi:10.3892/br.2014.272

    CAS  PubMed Central  PubMed  Google Scholar 

  14. Johnson JA, Burkley BM, Langaee TY, Clare-Salzler MJ, Klein TE, Altman RB (2012) Implementing personalized medicine: development of a cost-effective customized pharmacogenetics genotyping array. Clin Pharmacol Ther 92:437–439. doi:10.1038/clpt.2012.125

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. 1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, MA DP, Durbin RM, Handsaker RE, Kang HM, Marth GT, GA MV (2012) An integrated map of genetic variation from 1,092 human genomes. Nature 491:56–65. doi:10.1038/nature11632

    Article  Google Scholar 

  16. Gourraud PA, Khankhanian P, Cereb N, Yang SY, Feolo M, Maiers M, Rioux JD, Hauser S, Oksenberg J (2014) HLA diversity in the 1000 Genomes dataset. PLoS One 9:e97282. doi:10.1371/journal.pone.0097282

    Article  PubMed Central  PubMed  Google Scholar 

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Author contributions

Guang-dan Zhu, Ashley A. Brenton, Alka Malhotra, Tanya A. Moreno, and Andria L. Del Tredici planned and designed this study. Bae J. Riley, Katherine E. Church, and Frank G. Espin performed genotyping. Guang-dan Zhu performed the data analysis. The manuscript was written by Guang-dan Zhu, with contributions from Alka Malhotra, Tanya A. Moreno, Jennifer M. Strickland, and Andria L. Del Tredici. All authors approved the manuscript.

Conflict of interest

All authors are employees of Millennium Health, LLC.

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Correspondence to Guang-dan Zhu or Andria L. Del Tredici.

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Zhu, Gd., Brenton, A.A., Malhotra, A. et al. Genotypes at rs2844682 and rs3909184 have no clinical value in identifying HLA-B*15:02 carriers. Eur J Clin Pharmacol 71, 1021–1023 (2015). https://doi.org/10.1007/s00228-015-1879-y

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  • DOI: https://doi.org/10.1007/s00228-015-1879-y

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