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Risk factors for non-adherence to antidepressant treatment in patients with mood disorders

  • Pharmacoepidemiology and Prescription
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Purpose

Adherence to antidepressant therapy by patients with depressive disorders is essential not only to achieve a positive patient outcome but also to prevent a relapse. The aim of this study was to identify potential modelling factors influencing adherence to antidepressant treatment by patients with mood disorders in the community mental health care setting

Methods

A total of 160 consecutive psychiatric outpatients attending two Community Mental Health Centres on Tenerife Island between September 2011 and May 2012 were asked to participate in the study; of these, 145 accepted. The Morisky self-report scale was used to assess adherence. The potential predictors examined included socio-demographic, clinical and therapeutic variables. The Clinical Global Impression-Severity and -Improvement scales and the Beck Depression Inventory were used for clinical assessment. Drug treatment side-effects were assessed using the “Self-report Antidepressant Side-Effect Checklist.” All participants were also asked to complete the "Drug Attitude Inventory" (DAI), "Beliefs about Medicine Questionnaire" (BMQ), and "Leeds Attitude towards concordance Scale". Discriminant analyses were performed to predict non-adherence.

Results

There was no clear correlation between adherence and the socio-demographic variables examined, but adherence was related to a positive attitude of the patients towards his/her treatment (DAI) and low scores in the BMQ-Harm and -Concern subscales. Non-adherence was also related to an increasing severity of depression and to the presence and severity of side-effects.

Conclusions

Among our study cohort, the profiles of adherent patients to antidepressant treatment were more closely associated with each patient’s attitudes and beliefs than to objective socio-demographic variables. The severity of depression played a relevant role in adherence, but whether this role is direct or an interaction with several concurrent factors is not yet clear. Side-effects were also closely related to adherence, as conditioned by frequent polypharmacy.

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Acknowledgements

This research was supported by Instituto de Salud Carlos III, FEDER Unión Europea (PI10/00955).

Conflict of Interest

None.

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Authors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of La Laguna, Campus de Ofra s/n, 38071, San Cristóbal de La Laguna, Canary Islands, Spain

    Carlos De las Cuevas

  2. Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Tenerife, Canary Islands, Spain

    Carlos De las Cuevas

  3. Department of Personality, Assessment and Psychological Treatments, University of La Laguna, San Cristóbal de La Laguna, Canary Islands, Spain

    Wenceslao Peñate

  4. Department of Clinical Pharmacology, University of La Laguna, San Cristóbal de La Laguna, Canary Islands, Spain

    Emilio J. Sanz

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  1. Carlos De las Cuevas
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  3. Emilio J. Sanz
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Correspondence to Carlos De las Cuevas.

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De las Cuevas, C., Peñate, W. & Sanz, E.J. Risk factors for non-adherence to antidepressant treatment in patients with mood disorders. Eur J Clin Pharmacol 70, 89–98 (2014). https://doi.org/10.1007/s00228-013-1582-9

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  • DOI: https://doi.org/10.1007/s00228-013-1582-9

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