References
Niehues T, Baumann U, Buchholz B et al (2006) Empfehlungen zur antiretroviralen Therapie bei HIV-infizierten Kindern - Konsensus-Statement der Pädiatrischen Arbeitsgemeinschaft AIDS (PAAD) und der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI). Mon.schr Kinderheilkd 154:565–577
Kumar GN, Dykstra J, Roberts EM et al (1999) Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos 27:902–908
Kumar GN, Rodrigues AD, Buko AM, Denissen JF (1996) Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther 277:423–431
Ingelman-Sundberg M (2005) Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J 5:6–13
Kirchheiner J, Brøsen K, Dahl ML et al (2001) CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages. Acta Psychiatr Scand 104:173–192
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gorny, M., Röhm, S., Läer, S. et al. Pharmacogenomic adaptation of antiretroviral therapy: overcoming the failure of lopinavir in an African infant with CYP2D6 ultrarapid metabolism. Eur J Clin Pharmacol 66, 107–108 (2010). https://doi.org/10.1007/s00228-009-0753-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00228-009-0753-1