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Cytochrome P450 and gene activation – cholesterol elimination and regression of atherosclerosis: author reply to the commentary

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References

  1. Pelkonen O, Hakkola J (2008) Cytochrome P450, induction and cholesterol – what are the connections? Eur J Clin Pharmacol 64:837–839

    Article  PubMed  Google Scholar 

  2. Luoma PV (2008) Cytochrome P450 and gene activation – from pharmacology to cholesterol elimination and regression of atherosclerosis. Eur J Clin Pharmacol 64:841–850

    Article  PubMed  CAS  Google Scholar 

  3. Raucy JL, Lasker J, Ozaki K, Zoleta V (2004) Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicol Sciences 79:233–241

    Article  CAS  Google Scholar 

  4. Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL (2007) Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor α. Drug Metab Dispos 35:1126–1134

    Article  PubMed  CAS  Google Scholar 

  5. Hsu MH, Savas Ü, Griffin KJ, Johnson EF (2007) Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin. J Biol Chem 282:5225–5236

    Article  PubMed  CAS  Google Scholar 

  6. Tamehiro N, Shigemoto-Mogami Y, Kakeya T, Okuhira K, Suzuki K, Sato R, Nagao T, Nishimaki-Mogami T (2007) Sterol regulatory element-binding protein-2 and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression. Mechanism underlying the unique response to cellular cholesterol status. J Biol Chem 282:21090–21099

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Biomedicine, Pharmacology, University of Helsinki, P.O. Box 63, FIN-00014, Helsinki, Finland

    Pauli V. Luoma

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  1. Pauli V. Luoma
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Correspondence to Pauli V. Luoma.

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Luoma, P.V. Cytochrome P450 and gene activation – cholesterol elimination and regression of atherosclerosis: author reply to the commentary. Eur J Clin Pharmacol 65, 105–106 (2009). https://doi.org/10.1007/s00228-008-0567-6

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  • DOI: https://doi.org/10.1007/s00228-008-0567-6

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