Abstract
Introduction
Low-dose pancuronium is known to affect serum cholinesterase activity (BChE); however, the dose-response effect of clinical doses of pancuronium on BChE has not been investigated.
Methods
Thirteen ASA I-II patients scheduled for elective surgery requiring muscle relaxation were enrolled in this study. All patients had normal BChE before surgery. Incremental doses of pancuronium (10, 20, 50, and 100 µg/kg) were injected in accordance with surgical needs every 45 min. BChE was measured 3 min after injection by an automatic colorimetric method.
Results
BChE decreased significantly in all except one patient in comparison to the baseline (P < 0.05). However all values remained within normal clinical range. A dose of 100 µg/kg yielded significant decrease in comparison to 10 µg/kg but not to other dosages. Linear regression was not significant for the dose-response relationship (P = 0.05).
Conclusion
After clinical incremental doses of pancuronium, BChE remained within clinical range.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Motamed C, Kirov K, Lieutaud T, Duvaldestin P (2000) The mechanism of pancuronium potentiation of mivacurium block: use of the isolated-arm technique. Anesth Analg 91:732–735
Motamed C, Menad R, Farinotti R et al (2003) Potentiation of mivacurium blockade by low dose of pancuronium: a pharmacokinetic study. Anesthesiology 98:1057–1062
Popovic L, Kunec-Vajic E (1990) [Inhibition of plasma cholinesterase by pancuronium and vecuronium]. Lijec Vjesn 112:142–143
Stoelting RK (1976) Serum cholinesterase activity following pancuronium and antagonism with neostigmine or pyridostigmine. Anesthesiology 45:674–678
Stovner J, Oftedal N, Holmboe J (1975) The inhibition of cholinesterases by pancuronium. Br J Anaesth 47:949–954
Motamed C, Kirov K, Combes X et al (2005) Interaction between mivacurium and pancuronium: impact of the order of administration. Eur J Clin Pharmacol 61:175–177
Ostergaard D, Engbaek J, Viby-Mogensen J (1989) Adverse reactions and interactions of the neuromuscular blocking drugs. Med Toxicol Adverse Drug Exp 4:351–368
Motamed C, Kirov K, Combes X et al (2002) Effect of metoclopramide on mivacurium-induced neuromuscular block. Acta Anaesthesiol Scand 46:214–216
Wogram J, Sturm A, Segner H, Liess M (2001) Effects of parathion on acetylcholinesterase, butyrylcholinesterase, and carboxylesterase in three-spined stickleback (Gasterosteus aculeatus) following short-term exposure. Environ Toxicol Chem 20:1528–1531
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Motamed, C., Fanen, P., Feiss, P. et al. Dose-response effect of serum butyrylcholinesterase activity after clinical doses of pancuronium. Eur J Clin Pharmacol 64, 1043–1045 (2008). https://doi.org/10.1007/s00228-008-0548-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00228-008-0548-9