References
Veronese ME, Miners JO, Randles D, Gregov D, Birkett DJ (1990) Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers. Clin Pharmacol Ther 47:403–411
Lee CR, Pieper JA, Frye RF, Hinderliter AL, Blaisdell JA, Goldstein JA (2003) Tolbutamide, flurbiprofen and losartan as probes of CYP2C9 activity in humans. J Clin Pharmacol 43:84–91
Lee CR, Pieper JA, Hinderliter AL, Blaisdell JA, Goldstein JA (2002) Evaluation of CYP2C9 metabolic activity with tolbutamide in CYP2C9*1 heterozygotes. Clin Pharmacol Ther 72:562–571
Kirchheiner J, Bauer S, Meineke I, Rohde W, Prang V, Meise C, et al (2002) Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers. Pharmacogenetics 12:101–109
Jetter A, Kinzig-Schippers M, Skott A, Lazar A, Tomalik-Scharte D, Kirchheiner J, et al (2004) Cytochrome P450 2C9 phenotyping using low-dose tolbutamide. Eur J Clin Pharmacol 60:165–171
Blaisdell J, Jorge-Nebert LF, Coulter S, Ferguson SS, Lee SJ, Chanas B, et al (2004) Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics 14:527–537
Acknowledgements
We would like to acknowledge Dr. Alan Hinderliter, Ms. Joyce Blaisdell, Dr. Joyce Goldstein, and the nursing staff of the UNC General Clinical Research Center for their help in performing the study. This investigation was supported in part by grant RR00046 from the General Clinical Research Centers program of the Division of Research Resources, National Institutes of Health.
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Lee, C.R., Hawke, R.L. & Pieper, J.A. Twenty-four hour tolbutamide plasma concentration as a phenotypic measure of CYP2C9 activity. Eur J Clin Pharmacol 61, 315–316 (2005). https://doi.org/10.1007/s00228-005-0922-9
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DOI: https://doi.org/10.1007/s00228-005-0922-9