Skip to main content
Log in

Hepatotoxicity due to a possible interaction between cytosine arabinoside and dipyridamole: a case report

  • Letter to the Editors
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V (2000) Beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem 275:1699–1707

    Article  CAS  PubMed  Google Scholar 

  2. Nachbaur K, Dietze O, Herold M, Thaler J, Braunsteiner H, Vogel W (1992) Fulminant hepatic failure after high-dose cytosine arabinoside and mitoxantrone treatment for relapse of acute myelogenous leukaemia. Eur J Haematol 49:221–223

    CAS  PubMed  Google Scholar 

  3. Nelson JA, Drake S (1984) Potentiation of methotrexate toxicity by dipyridamole. Cancer Res 44:2493–2496

    CAS  PubMed  Google Scholar 

  4. Tanaka M, Kanamori H, Yamaji S, Mishima A, Fujita H, Fujisawa S, Murata T, Koharazawa H, Matsuzaki M, Mohri H (1999) Low-dose cytarabine-induced hepatic and renal dysfunction in a patient with myelodysplastic syndrome. Anticancer Drugs 10:289–291

    CAS  PubMed  Google Scholar 

  5. Terlouw SA, Masereeuw R, Russel FG, Miller DS (2001) Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux. Mol Pharmacol 59:1433–1440

    CAS  PubMed  Google Scholar 

  6. Yang JL, White JC, Capizzi RL (1990) Enhanced retention of cytosine arabinoside and its metabolites and synergistic cytotoxicity by sequential treatment with dipyridamole in L5178Y leukemia. Cancer Chemother Pharmacol 26:135–138

    CAS  PubMed  Google Scholar 

  7. Yang JL, White JC, Capizzi RL (1992) Modulation of the cellular pharmacokinetics of ara-CTP in human leukemic blasts by dipyridamole. Cancer Chemother Pharmacol 29:236–240

    CAS  PubMed  Google Scholar 

  8. Yue L, Saikawa Y, Ota K, Tanaka M, Nishimura R, Uehara T, Maeba H, Ito T, Sasaki T, Koizumi S (2003) A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity. Pharmacogenetics 13:29–38

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Melih O. Babaoglu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Babaoglu, M.O., Karadag, O., Saikawa, Y. et al. Hepatotoxicity due to a possible interaction between cytosine arabinoside and dipyridamole: a case report. Eur J Clin Pharmacol 60, 455–456 (2004). https://doi.org/10.1007/s00228-004-0790-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00228-004-0790-8

Keywords

Navigation