Abstract
Aim
Homotoxicology is a form of therapy that uses homoeopathically diluted remedies with a view of eliminating toxins from the body. It is not a therapeutic method based on accepted scientific principles or biological plausibility. Yet numerous clinical studies have claimed efficacy. The aim of this systematic review is to summarise and critically evaluate the evidence from rigorous clinical trials of this form of therapy.
Methods
Seven electronic databases were searched for all studies of homotoxicological medicines for any human condition. To be included, trials had to be randomised and placebo-controlled. Data from such studies were validated and extracted according to pre-defined criteria. Their methodological quality was formally assessed using the Jadad score. Key data of all included trials were tabulated and summarised in narrative form.
Results
Seven trials met our inclusion criteria. Their Jadad scores indicated mostly a high methodological standard. The trials tested the efficacy of seven different medicines for seven different indications. The results were positive in all but one study. Important flaws were found in all trials. These render the results of the primary studies less reliable than their high Jadad scores might suggest.
Conclusion
Despite mostly positive findings and high ratings on the Jadad score, the placebo-controlled, randomised clinical trials of homotoxicology fail to demonstrate the efficacy of this therapeutic approach.
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References
Reckeweg HH (1986) Homotoxikologie, Ganzschau einer Synthese der Medizin, 6th edn. Aurelia Verlag, Stuttgart
Linde K, Clausius N, Ramirez G et al (1997) Are the clinical effects of homoeopathy placebo effects? A meta-analysis of placebo-controlled trials. Lancet 350:834–843
Ernst E (2002) A systematic review of systematic reviews of homeopathy. Br J Clin Pharmacol 54:577–582
Mathie RT (2003) The research evidence base for homeopathy: a fresh assessment of the literature. Homeopathy 92:84–91
Jadad AR, Moore RA, Carrol D et al (1996) Assessing the quality of reports of randomized clinical trials—is blinding necessary? Control Clin Trials 17:1–12
Zell VJ, Connert W-D, Mau J, Feuerstake G (1988) Behandlung von akuten Sprunggelenksdistorsionen. Fortschr Med Suppl 5:62–70
Maiwald L, Weinfurtner T, Mau J, Connert WD (1988) Therapie des grippalen Infekts mit einem homöopathischen Kombinationspräparat im Vergleich zu Acetylsalicylsäure. Arzneimittelforschung 38:578–582
Thiel W, Borho B (1991) Die Therapie von frischen, traumatischen Blutergüssen der Kniegelenke (Hämarthros) mit Traumeel N Injektionslösung. Biol Med 2:506–515
Zenner S, Metelmann H (1991) Die Behandlung der vegetativen Dystonie mit Ypsiloheel. Ärztezeitschrift Naturheilverfahren 8:646–652
Zenner BS, Metelmann H (1991) Schwindel und seine Beeinflußbarkeit durch ein homöopathisches Kombinationspräparat. Erfahrungsheilk 6:422–429
Heilmann A (1992) Ein injizierbares Kombinationspräparat (Engystol N) als Prophylaktikum des grippalen Infekts. Biol Med 3:225–229
Böhmer D, Ambrus P (1992) Behandlung von Sportverletzungen mit Traumeel-Salbe. Kontrollierte Doppelblindstudie. Biol Med 21:260–268
Weiser M, Clasen BP (1994) Randomisierte plazebokontrollierte Doppelblindstudie zur Untersuchung der klinischen Wirksamkeit der homopathischen Euphorbium compositum-Nasen-Tropfen S bei chronischer Sinusitis. Forsch Komplementarmed 1:251–259
Weiser M, Gegenheimer LH, Klein P (1996) A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-heel nasal spray with Cromolyn sodium spray in the treatment of seasonal allergic rhinitis. Forsch Komplementarmed 6:142–148
Weiser M, Strosser W, Klein P (1998) Homeopathic vs conventional treatment of vertigo—a randomised double-blind controlled clinical study. Arch Otolaryngol Head Neck Surg 124:879–885
Nahler G, Metelmann H, Sperber H (1998) Treating osteoarthritis of the knee with a homeopathic preparation. Results of a randomized, controlled, clinical trial in comparison to hyalauric acid. Biomed Ther 16:186–191
Matusiewicz R, Wasniewski J, Sterna-Bazanska A, Hülsberg M (1999) Behandlung des chronischen Asthma bronchiale mit einem homöopathischen Komplexmittel. Erfahrungsheilk 6:367–374
Reus V, Weiser M (1999) Homeopathic therapy of gynaecological disorders. Biol Med 28:233–236
Maronna U, Weiser M, Klein P (2000) Orale Behandlung der Gonarthrose mit Zeel comp. Ortopädische Praxis 36:285–291
Dietz A-R (2000) Möglichkeiten einer Lymphtherapie bei diabetischer Polyneuropathie. Biol Med 29:4–9
Weiser M, Strösser W (2000) Behandlung des Schwindels. Vergleichsstudie Homöopathikum vs. Betahistin. Allgemeinarzt 13:962–964
Oberbaum M, Yaniv I, Ben-Gal Y et al (2001) A randomized, controlled clinical trial of the homeopathic medication Traumeel S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation. Cancer 92:684–690
Glatthaar-Saalmüller B, Fallier-Becker P (2001) Antiviral action of Euphorbium compositum and its components. Forsch Komplementarmed 8:207–212
Hülsberg M (2001) Wirksamkeit einses homöopathischen Komplexmittels im Rahmen einer Amalgam-Eliminierungstherapie in der zahnärztlichen Praxis. Erfahrungsheilk 1:32–39
Wolschner U, Strösser W, Weiser M, Klein P (2001) Behandlung des Schwindels mit einem modernen Homöopathikum. Biol Med 30:184–190
Heine H, Andrä F (2002) Zum antiinflammatorischen Wirkmechanismus eines Antihomotoxikum compositum. Ärztezeitschrift Naturheilverfahren 43:96–104
Müller-Krampe B, Gottwald R, Weiser M (2002) Symptomatische Behandlung von akuten fieberhaften Infekten mit einem modernen Homöopathikum. Biol Med 31:79–85
Zell J, Connert WD, Mau J, Feuerstake G (1989) Treatment of acute sprains of the ankle: a controlled double-blind trial to test the effectiveness of a homeopathic ointment. Biol Ther 7:1–6
Betz W (2002) The memory of water revisited. Sci Rev Altern Med 6:68–72
Weiser M. E-mail to Professor Edzard Ernst, dated 27th Feb 2003
Acknowledgements
Conflict of interest: we asked one manufacturer for funding but were not successful. Support: E.E.’s work was financed from his unit’s core funding. K.S. was supported by the ‘Pilkington Family Trusts’.
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Ernst, E., Schmidt, K. Homotoxicology—a review of randomised clinical trials. Eur J Clin Pharmacol 60, 299–306 (2004). https://doi.org/10.1007/s00228-004-0776-6
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DOI: https://doi.org/10.1007/s00228-004-0776-6