Abstract
Objective
This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese.
Methods
Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations—G238C, G460A and A719G.
Results
One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively.
Conclusion
TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese.
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Acknowledgements
The authors thank Dr. Weinshilboum (Mayo Medical School, Mayo Clinic, Rochester, USA) for providing DNA reference samples. This work was supported by the National Nature Science Fund of China (No. 30171098). The experiments comply with the current law of the People’s Republic of China.
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Zhang, JP., Guan, YY., Xu, AL. et al. Gene mutation of thiopurine S-methyltransferase in Uygur Chinese. Eur J Clin Pharmacol 60, 1–3 (2004). https://doi.org/10.1007/s00228-004-0730-7
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DOI: https://doi.org/10.1007/s00228-004-0730-7