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Calcified Tissue International

, Volume 64, Issue 2, pp 93–99 | Cite as

Risedronate, a Highly Effective, Short-Term Oral Treatment for Paget's Disease: A Dose-Response Study

  • J. P.  Brown
  • D. J.  Hosking
  • L.-G.  Ste-Marie
  • C. C.  Johnston, Jr
  • J.-Y.  Reginster
  • W. G.  Ryan
  • T. D.  Johnson
  • P. J.  Bekker

Abstract.

Risedronate is a potent pyridinyl bisphosphonate being developed for bone diseases such as Paget's disease and osteoporosis. In this study, we compared the efficacy, safety, and tolerability of three different doses of oral risedronate in 62 patients with severe Paget's disease of bone [serum alkaline phosphatase (AP) >3 times the upper limit of normal]. Patients were treated at six study centers with either 10, 20, or 30 mg oral risedronate daily for 28 days and followed up to day 85. The primary efficacy parameter was percentage change from baseline in AP excess. The data show that there is a dose-response with risedronate: patients who received 30 mg oral risedronate for 28 days benefited most, with a mean percentage decrease in AP excess of 72.2% (20 mg: 57.9%; 10 mg: 48.0%). Time to response—the first time point when there was a ≥30% reduction from baseline in AP excess and ≥50% reduction from baseline in urinary hydroxyproline (HP)/creatinine–was also significantly shorter (median 29 days) in the 30 mg group compared with the other two groups (20 mg: 43 days and 10 mg: 71 days). Long-term follow-up data up to 33 months from the start of the study indicated that AP remained below baseline levels for all patients. Histologic evaluation of bone formed during risedronate therapy demonstrated that normal lamellar bone was formed as opposed to woven pagetic bone, with no evidence of osteomalacia. Risedronate was well tolerated. Transient decreases in serum calcium and increases in serum intact parathyroid hormone were observed, consistent with the pharmacology of risedronate. In conclusion, risedronate administered at daily doses of 10, 20, and 30 mg for 28 days was effective in reducing the biochemical indices of disease activity in patients with severe Paget's disease of bone. A daily dose of 30 mg was most effective without compromising safety or tolerability.

Key words: Risedronate — Bisphosphonate — Paget's disease. 

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Copyright information

© Springer-Verlag New York Inc. 1999

Authors and Affiliations

  • J. P.  Brown
    • 1
  • D. J.  Hosking
    • 2
  • L.-G.  Ste-Marie
    • 3
  • C. C.  Johnston, Jr
    • 4
  • J.-Y.  Reginster
    • 5
  • W. G.  Ryan
    • 6
  • T. D.  Johnson
    • 7
  • P. J.  Bekker
    • 7
  1. 1.Le Centre hospitalier universitaire de Québec, Pavillon CHUL, S-782, 2705 boul. Laurier, Ste-Foy, Québec, Canada, G1V 4G2CA
  2. 2.Nottingham City Hospital, Nottingham, United KingdomGB
  3. 3.Centre de recherche clinique André-Viallet, Hôpital Saint-Luc, Montréal, Québec, CanadaCA
  4. 4.Department of Medicine, Endocrinology Division, Indiana University Medical Center, Indianapolis, Indiana, USAUS
  5. 5.Department of Epidemiology and Public Health and Bone and Cartilage Research Unit, University of Liege, Liege, BelgiumBE
  6. 6.Rush-Presbyterian/St. Luke's Medical Center, Chicago, Illinois, USAUS
  7. 7.Procter & Gamble Pharmaceuticals, Cincinnati, Ohio, USAUS

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