Skip to main content

Advertisement

SpringerLink
Log in

Changes in the Concentration of Insulin-Like Growth Factor I and Transforming Growth Factor β1 in Rat Femoral Bone during Growth

  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Abstract.

Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-β) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGF-β in all compartments of the femoral bone. The association between IGF-I and TGF-β is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-β play an important role in the growth-associated accumulation of bone mass.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Internal Medicine I, University of Heidelberg, Luisenstraße 5, D-69115, Heidelberg, Germany, DE

    J. Pfeilschifter, J. Erdmann, S. Storch & R. Ziegler

  2. Department of Oral Biology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 69978, Israel, IL

    M. Weinreb

Authors
  1. J. Pfeilschifter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Erdmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Storch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Ziegler
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Weinreb
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 16 April 1997 / Accepted: 9 July 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pfeilschifter, J., Erdmann, J., Storch, S. et al. Changes in the Concentration of Insulin-Like Growth Factor I and Transforming Growth Factor β1 in Rat Femoral Bone during Growth. Calcif Tissue Int 64, 78–82 (1999). https://doi.org/10.1007/s002239900582

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002239900582

Search

Navigation