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Severe, Diffuse Osteosclerosis: A New Manifestation of Transitional Cell Carcinoma of the Urinary Bladder

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Abstract.

A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum acid phosphatase and prostatic-specific antigen (PSA) were normal. Serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were just below the normal limit and parathyroid hormone was moderately elevated. A transiliac bone biopsy specimen revealed expanded bone trabeculae, abundance of osteoid-covered surfaces, and heavy metastatic spread. To the best of our knowledge, this is the first description of the association of osteosclerosis and metastatic transitional-cell carcinoma of the bladder.

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Authors and Affiliations

  1. Bone and Mineral Metabolism and Endocrine Units, Ben-Gurion University of the Negev, Beer-Sheva, Israel, , , , , , IL

    Y. Liel

  2. Department of Medicine, Ben-Gurion University of the Negev, Beer-Sheva, Israel, , , , , , IL

    M. N. Lowenthal

  3. Institute of Pathology, Ben-Gurion University of the Negev, Beer-Sheva, Israel, , , , , , IL

    E. Maor

  4. Institute of Oncology, Soroka Medical Center of Kupat Holim, and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, , , , , , IL

    S. Ariad

Authors
  1. Y. Liel
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  2. E. Maor
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  3. S. Ariad
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  4. M. N. Lowenthal
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Received: 6 March 1998 / Accepted: 12 May 1998

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Liel, Y., Maor, E., Ariad, S. et al. Severe, Diffuse Osteosclerosis: A New Manifestation of Transitional Cell Carcinoma of the Urinary Bladder. Calcif Tissue Int 63, 471–474 (1998). https://doi.org/10.1007/s002239900560

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  • DOI: https://doi.org/10.1007/s002239900560

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