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Stimulation of Bone Formation In Vivo by Insulin-Like Growth Factor-II in Rats

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Abstract.

Insulin-like growth factor-II (IGF-II) plays an important role in skeletal remodeling, however, little is known about its effect on bone formation in vivo. In our study of the stimulation of bone formation in vivo by IGF II we injected recombinant human IGF-II into the parietal bones of neonatal rats once a day for 12 days. The bone mineral density measured by dual energy X-ray absorptiometry and the thickness of IGF-II-injected parietal bones increased in a dose-dependent manner. The layers of osteoblasts were observed along the IGF-II-injected side.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, NTT (Nippon Telegraph and Telephone Corporation) Sapporo Hospital, South 1 West 15, Sapporo 060, Japan, , , , , , JP

    M. Ishibe

  2. Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan, , , , , , JP

    T. Ishibashi

  3. Department of Orthopaedics, Hokkaido University School of Medicine, Sapporo 060, Japan, , , , , , JP

    K. Kaneda

  4. Institute of Immunological Science, Hokkaido University School of Medicine, Sapporo 060, Japan, , , , , , JP

    T. Koda

  5. Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14620, USA, , , , , , US

    R. N. Rosier & J. E. Puzas

Authors
  1. M. Ishibe
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  2. T. Ishibashi
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  3. K. Kaneda
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  4. T. Koda
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  5. R. N. Rosier
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  6. J. E. Puzas
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Received: 12 June 1997 / Accepted: 8 January 1998

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Ishibe, M., Ishibashi, T., Kaneda, K. et al. Stimulation of Bone Formation In Vivo by Insulin-Like Growth Factor-II in Rats. Calcif Tissue Int 63, 36–38 (1998). https://doi.org/10.1007/s002239900486

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  • DOI: https://doi.org/10.1007/s002239900486

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