Abstract.
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 μM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.
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Received: 15 July 1996/Accepted: 10 December 1996
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Teronen, O., Konttinen, Y., Lindqvist, C. et al. Inhibition of Matrix Metalloproteinase-1 by Dichloromethylene Bisphosphonate (Clodronate). Calcif Tissue Int 61, 59–61 (1997). https://doi.org/10.1007/s002239900295
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DOI: https://doi.org/10.1007/s002239900295