Skip to main content

Advertisement

SpringerLink
Log in

Vitamin D and Skeletal Muscle: Emerging Roles in Development, Anabolism and Repair

  • Review
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Abstract

This special issue article will focus on morphologic and functional roles of vitamin D in muscle, from strength to contraction to development and ageing and will characterise the controversy of VDR’s expression in skeletal muscle, central to our understanding of vitamin D’s effects on this tissue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Floyd M, Ayyar DR, Barwick DD, Hudgson P, Weightman D (1974) Myopathy in chronic renal failure. Q J Med 43(172):509–524

    CAS  PubMed  Google Scholar 

  2. Girgis CM, Clifton-Bligh RJ, Hamrick MW, Holick MF, Gunton JE (2013) The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev 34(1):33–83

    CAS  PubMed  Google Scholar 

  3. Whistler D (1645) De morbo puerili Anglorum quem patrio idiomate indigenae vocant. The Rickets. Londini, London

    Google Scholar 

  4. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK et al (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96(1):53–58

    CAS  PubMed  Google Scholar 

  5. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF et al (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29(6):726–776

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Cui X, Pelekanos M, Liu PY, Burne TH, McGrath JJ, Eyles DW (2013) The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience 236:77–87

    CAS  PubMed  Google Scholar 

  7. Brumbaugh PF, Haussler MR (1974) 1 Alpha,25-dihydroxycholecalciferol receptors in intestine. I. Association of 1 alpha,25-dihydroxycholecalciferol with intestinal mucosa chromatin. J Biol Chem 249(4):1251–1257

    CAS  PubMed  Google Scholar 

  8. Girgis CM (2018) Vitamin D and skeletal muscle. In: Feldman DJPW, Bouillon R, Giovanucci E, Goltzman D, Hewison M (eds) Vitamin D. Elsevier, Atlanta, pp 597–613

    Google Scholar 

  9. Wang Y, Becklund BR, DeLuca HF (2010) Identification of a highly specific and versatile vitamin D receptor antibody. Arch Biochem Biophys 494(2):166–177

    CAS  PubMed  Google Scholar 

  10. Simpson RU, Thomas GA, Arnold AJ (1985) Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem 260(15):8882–8891

    CAS  PubMed  Google Scholar 

  11. Costa EM, Blau HM, Feldman D (1986) 1,25-Dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells. Endocrinology 119(5):2214–2220

    CAS  PubMed  Google Scholar 

  12. Endo I, Inoue D, Mitsui T, Umaki Y, Akaike M, Yoshizawa T et al (2003) Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144(12):5138–5144

    CAS  PubMed  Google Scholar 

  13. Ceglia L, da Silva Morais M, Park LK, Morris E, Harris SS, Bischoff-Ferrari HA et al (2010) Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle. J Mol Histol 41(2–3):137–142

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Girgis CM, Mokbel N, Minn Cha K, Houweling PJ, Abboud M, Fraser DR et al (2014) The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology 155(9):3227–3237

    PubMed  PubMed Central  Google Scholar 

  15. Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin HB et al (2001) In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 33(1):19–24

    CAS  PubMed  Google Scholar 

  16. Buitrago C, Boland R (2010) Caveolae and caveolin-1 are implicated in 1alpha,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells. J Steroid Biochem Mol Biol 121(1–2):169–175

    CAS  PubMed  Google Scholar 

  17. Wang Y, DeLuca HF (2011) Is the vitamin d receptor found in muscle? Endocrinology 152(2):354–363

    CAS  PubMed  Google Scholar 

  18. Olsson K, Saini A, Stromberg A, Alam S, Lilja M, Rullman E et al (2016) Evidence for vitamin D receptor expression and direct effects of 1 alpha, 25(OH)2D3 in human skeletal muscle precursor cells. Endocrinology 157(1):98–111

    CAS  PubMed  Google Scholar 

  19. Ceglia L, Niramitmahapanya S, Morais MD, Rivas DA, Harris SS, Bischoff-Ferrari H et al (2013) A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab 98(12):1927–1935

    Google Scholar 

  20. Pojednic RM, Ceglia L, Olsson K, Gustafsson T, Lichtenstein AH, Dawson-Hughes B et al (2015) Effects of 1,25-dihydroxyvitamin D3 and vitamin D3 on the expression of the vitamin d receptor in human skeletal muscle cells. Calcif Tissue Int 96(3):256–263

    CAS  PubMed  Google Scholar 

  21. Lee SM, Bishop KA, Goellner JJ, O’Brien CA, Pike JW (2014) Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype. Endocrinology 155(6):2064–2076

    PubMed  PubMed Central  Google Scholar 

  22. Capiati D, Benassati S, Boland RL (2002) 1,25(OH)2-Vitamin D3 induces translocation of the vitamin D receptor (VDR) to the plasma membrane in skeletal muscle cells. J Cell Biochem 86(1):128–135

    CAS  PubMed  Google Scholar 

  23. Buitrago C, de Boland R, Boland AR (2001) The tyrosine kinase c-Src is required for 1,25(OH)2-vitamin D3 signalling to the nucleus in muscle cells. Biochimica et Biophysica Acta. 1541(3):179–187

    CAS  PubMed  Google Scholar 

  24. Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN (2011) 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells. Endocrinology 152(8):2976–2986

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Makanae Y, Ogasawara R, Sato K, Takamura Y, Matsutani K, Kido K et al (2015) Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle. Exp Physiol 100(10):1168–1176

    CAS  PubMed  Google Scholar 

  26. Srikuea R, Zhang X, Park-Sarge OK, Esser KA (2012) VDR and CYP27B1 are expressed in C2C12 cells and regenerating skeletal muscle: potential role in suppression of myoblast proliferation. Am J Physiol Cell Physiol 303(4):C396–C405

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Cheng C, Alexander R, Min R, Leng J, Yip KY, Rozowsky J et al (2012) Understanding transcriptional regulation by integrative analysis of transcription factor binding data. Genome Res 22(9):1658–1667

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Yin H, Price F, Rudnicki MA (2013) Satellite cells and the muscle stem cell niche. Physiol Rev 93(1):23–67

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Johnson JA, Grande JP, Roche PC, Kumar R (1996) Ontogeny of the 1,25-dihydroxyvitamin D3 receptor in fetal rat bone. J Bone Miner Res 11(1):56–61

    CAS  PubMed  Google Scholar 

  30. Artaza JN, Norris KC (2009) Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. J Endocrinol 200(2):207–221

    CAS  PubMed  Google Scholar 

  31. Garcia LA, Ferrini MG, Norris KC, Artaza JN (2013) 1,25(OH)(2)Vitamin D(3) enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C(2)C(12) skeletal muscle cells. J Steroid Biochem Mol Biol 133:1–11

    CAS  PubMed  Google Scholar 

  32. Girgis CM, Clifton-Bligh RJ, Mokbel N, Cheng K, Gunton JE (2014) Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells. Endocrinology 155(2):347–357

    CAS  PubMed  Google Scholar 

  33. Morelli S, Buitrago C, Boland R, de Boland AR (2001) The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium. Mol Cell Endocrinol 173(1–2):41–52

    CAS  PubMed  Google Scholar 

  34. Buitrago CG, Pardo VG, de Boland AR, Boland R (2003) Activation of RAF-1 through Ras and protein kinase Calpha mediates 1alpha,25(OH)2-vitamin D3 regulation of the mitogen-activated protein kinase pathway in muscle cells. J Biol Chem 278(4):2199–2205

    CAS  PubMed  Google Scholar 

  35. Ronda AC, Buitrago C, Colicheo A, de Boland AR, Roldan E, Boland R (2007) Activation of MAPKs by 1alpha,25(OH)2-Vitamin D3 and 17beta-estradiol in skeletal muscle cells leads to phosphorylation of Elk-1 and CREB transcription factors. J Steroid Biochem Mol Biol 103(3–5):462–466

    CAS  PubMed  Google Scholar 

  36. Boland R, De Boland AR, Buitrago C, Morelli S, Santillan G, Vazquez G et al (2002) Non-genomic stimulation of tyrosine phosphorylation cascades by 1,25(OH)(2)D(3) by VDR-dependent and independent mechanisms in muscle cells. Steroids 67(6):477–482

    CAS  PubMed  Google Scholar 

  37. Tanaka M, Kishimoto KN, Okuno H, Saito H, Itoi E (2014) Vitamin D receptor gene silencing effects on differentiation of myogenic cell lines. Muscle Nerve 49(5):700–708

    CAS  PubMed  Google Scholar 

  38. Girgis CM, Cha KM, Houweling PJ, Rao R, Mokbel N, Lin M et al (2015) Vitamin D receptor ablation and vitamin D deficiency result in reduced grip strength, altered muscle fibers, and increased myostatin in mice. Calcif Tissue Int 97(6):602–610

    CAS  PubMed  Google Scholar 

  39. Seoane S, Alonso M, Segura C, Perez-Fernandez R (2002) Localization of a negative vitamin D response sequence in the human growth hormone gene. Biochem Biophys Res Commun 292(1):250–255

    CAS  PubMed  Google Scholar 

  40. Sakoda K, Fujiwara M, Arai S, Suzuki A, Nishikawa J, Imagawa M et al (1996) Isolation of a genomic DNA fragment having negative vitamin D response element. Biochem Biophys Res Commun 219(1):31–35

    CAS  PubMed  Google Scholar 

  41. Chen S, Villalta SA, Agrawal DK (2016) FOXO1 mediates vitamin D deficiency-induced insulin resistance in skeletal muscle. J Bone Miner Res 31(3):585–595

    CAS  PubMed  Google Scholar 

  42. Krishnaveni GV, Veena SR, Winder NR, Hill JC, Noonan K, Boucher BJ et al (2011) Maternal vitamin D status during pregnancy and body composition and cardiovascular risk markers in Indian children: the Mysore Parthenon Study. Am J Clin Nutr 93(3):628–635

    CAS  PubMed  Google Scholar 

  43. Harvey NC, Moon RJ, Sayer AA, Ntani G, Davies JH, Javaid MK et al (2014) Maternal antenatal vitamin D status and offspring muscle development: findings from the Southampton Women’s Survey. J Clin Endocrinol Metab 99(1):330–337

    CAS  PubMed  Google Scholar 

  44. Max D, Brandsch C, Schumann S, Kuhne H, Frommhagen M, Schutkowski A et al (2013) Maternal vitamin D deficiency causes smaller muscle fibers and altered transcript levels of genes involved in protein degradation, myogenesis, and cytoskeleton organization in the newborn rat. Mol Nutr Food Res 58:343–352

    PubMed  Google Scholar 

  45. Oku Y, Tanabe R, Nakaoka K, Yamada A, Noda S, Hoshino A et al (2016) Influences of dietary vitamin D restriction on bone strength, body composition and muscle in rats fed a high-fat diet: involvement of mRNA expression of MyoD in skeletal muscle. J Nutr Biochem 32:85–90

    CAS  PubMed  Google Scholar 

  46. Zhou H, Chen Y, Lv G, Zhuo Y, Lin Y, Feng B et al (2016) Improving maternal vitamin D status promotes prenatal and postnatal skeletal muscle development of pig offspring. Nutrition 32(10):1144–1152

    CAS  PubMed  Google Scholar 

  47. Alami-Durante H, Cluzeaud M, Bazin D, Mazurais D, Zambonino-Infante JL (2011) Dietary cholecalciferol regulates the recruitment and growth of skeletal muscle fibers and the expressions of myogenic regulatory factors and the myosin heavy chain in European sea bass larvae. J Nutr 141(12):2146–2151

    CAS  PubMed  Google Scholar 

  48. Harvey NC, Sheppard A, Godfrey KM, McLean C, Garratt E, Ntani G et al (2014) Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth. J Bone Miner Res 29(3):600–607

    CAS  PubMed  Google Scholar 

  49. Girgis CM, Clifton-Bligh RJ, Turner N, Lau SL, Gunton JE (2014) Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity. Clin Endocrinol (Oxf). 80(2):169–181

    CAS  PubMed  Google Scholar 

  50. Burne TH, Johnston AN, McGrath JJ, Mackay-Sim A (2006) Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice. Brain Res Bull 69(1):74–78

    CAS  PubMed  Google Scholar 

  51. Minasyan A, Keisala T, Zou J, Zhang Y, Toppila E, Syvala H et al (2009) Vestibular dysfunction in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol 114(3–5):161–166

    CAS  PubMed  Google Scholar 

  52. Schubert L, DeLuca HF (2010) Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiency. Arch Biochem Biophys 500(2):157–161

    CAS  PubMed  Google Scholar 

  53. Rodman JS, Baker T (1978) Changes in the kinetics of muscle contraction in vitamin D-depleted rats. Kidney Int 13(3):189–193

    CAS  PubMed  Google Scholar 

  54. Pleasure D, Wyszynski B, Sumner A, Schotland D, Feldman B, Nugent N et al (1979) Skeletal muscle calcium metabolism and contractile force in vitamin D-deficient chicks. J Clin Investig 64(5):1157–1167

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Pointon JJ, Francis MJ, Smith R (1979) Effect of vitamin D deficiency on sarcoplasmic reticulum function and troponin C concentration of rabbit skeletal muscle. Clin Sci (Lond). 57(3):257–263

    CAS  PubMed  Google Scholar 

  56. Stroder J, Arensmeyer E (1965) Actomyosin content of the skeletal muscles in experimental rickets. Klin Wochenschr 43(22):1201–1202

    CAS  PubMed  Google Scholar 

  57. de Boland AR, Albornoz LE, Boland R (1983) The effect of cholecalciferol in vivo on proteins and lipids of skeletal muscle from rachitic chicks. Calcif Tissue Int 35(6):798–805

    PubMed  Google Scholar 

  58. Curry OB, Basten JF, Francis MJ, Smith R (1974) Calcium uptake by sarcoplasmic reticulum of muscle from vitamin D-deficient rabbits. Nature 249(452):83–84

    CAS  PubMed  Google Scholar 

  59. Tague SE, Clarke GL, Winter MK, McCarson KE, Wright DE, Smith PG (2011) Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation. J Neurosci 31(39):13728–13738

    CAS  PubMed  PubMed Central  Google Scholar 

  60. Sakai S, Suzuki M, Tashiro Y, Tanaka K, Takeda S, Aizawa K et al (2015) Vitamin D receptor signaling enhances locomotive ability in mice. J Bone Miner Res 30(1):128–136

    CAS  PubMed  Google Scholar 

  61. Abboud M, Puglisi DA, Davies BN, Rybchyn M, Whitehead NP, Brock KE et al (2013) Evidence for a specific uptake and retention mechanism for 25-hydroxyvitamin D (25OHD) in skeletal muscle cells. Endocrinology 154(9):3022–3030

    CAS  PubMed  Google Scholar 

  62. Vazquez G, Boland R, de Boland AR (1995) Modulation by 1,25(OH)2-vitamin D3 of the adenylyl cyclase/cyclic AMP pathway in rat and chick myoblasts. Biochim Biophys Acta 1269(1):91–97

    PubMed  Google Scholar 

  63. Capiati DA, Vazquez G, Boland RL (2001) Protein kinase C alpha modulates the Ca2+ influx phase of the Ca2+ response to 1alpha,25-dihydroxy-vitamin-D3 in skeletal muscle cells. Horm Metab Res 33(4):201–206

    CAS  PubMed  Google Scholar 

  64. Boland RL (2011) VDR activation of intracellular signaling pathways in skeletal muscle. Mol Cell Endocrinol 347(1–2):11–16

    CAS  PubMed  Google Scholar 

  65. Morelli S, de Boland AR, Boland RL (1993) Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3. Biochem J. 289(Pt 3):675–679

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Berchtold MW, Brinkmeier H, Muntener M (2000) Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease. Physiol Rev 80(3):1215–1265

    CAS  PubMed  Google Scholar 

  67. Sohl E, van Schoor NM, de Jongh RT, Visser M, Deeg DJ, Lips P (2013) Vitamin d status is associated with functional limitations and functional decline in older individuals. J Clin Endocr Metab 98(9):E1483–E1490

    CAS  PubMed  Google Scholar 

  68. Bhat M, Kalam R, Qadri SS, Madabushi S, Ismail A (2013) Vitamin D deficiency induced muscle wasting occurs through the ubiquitin proteasome pathway and is partially corrected by calcium in male rats. Endocrinology 154(11):4018–4029

    CAS  PubMed  Google Scholar 

  69. Antinozzi C, Corinaldesi C, Giordano C, Pisano A, Cerbelli B, Migliaccio S et al (2017) Potential role for the VDR agonist elocalcitol in metabolic control: evidences in human skeletal muscle cells. J Steroid Biochem Mol Biol 167:169–181

    CAS  PubMed  Google Scholar 

  70. Montero-Odasso M, Duque G (2005) Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone. Mol Aspects Med 26(3):203–219

    CAS  PubMed  Google Scholar 

  71. Phelps M, Pettan-Brewer C, Ladiges W, Yablonka-Reuveni Z (2013) Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice. Biogerontology 14(6):729–739

    CAS  PubMed  Google Scholar 

  72. Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C et al (2012) Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study. Eur J Appl Physiol 112(4):1215–1220

    PubMed  Google Scholar 

  73. Bhat M, Ismail A (2015) Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis. J Steroid Biochem Mol Biol 152:171–179

    CAS  PubMed  Google Scholar 

  74. Sinha A, Hollingsworth KG, Ball S, Cheetham T (2013) Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. J Clin Endocr Metab 98(3):E509–E513

    CAS  PubMed  Google Scholar 

  75. Al-Eisa ES, Alghadir AH, Gabr SA (2016) Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults. Clin Interv Aging 11:513–522

    CAS  PubMed  PubMed Central  Google Scholar 

  76. Ryan ZC, Craig TA, Folmes CD, Wang X, Lanza IR, Schaible NS et al (2016) 1alpha,25-Dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells. J Biol Chem 291(3):1514–1528

    CAS  PubMed  Google Scholar 

  77. Owens DJ, Sharples AP, Polydorou I, Alwan N, Donovan T, Tang J et al (2015) A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy. Am J Physiol Endocrinol Metab. 309(12):E1019–E1031

    CAS  PubMed  Google Scholar 

  78. Stratos I, Li Z, Herlyn P, Rotter R, Behrendt AK, Mittlmeier T et al (2013) Vitamin D increases cellular turnover and functionally restores the skeletal muscle after crush injury in rats. Am J Pathol 182(3):895–904

    CAS  PubMed  Google Scholar 

  79. Choi M, Park H, Cho S, Lee M (2013) Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high-intensity exercise in SD rats. Cytokine 63(1):27–35

    CAS  PubMed  Google Scholar 

  80. Ke CY, Yang FL, Wu WT, Chung CH, Lee RP, Yang WT et al (2016) Vitamin D3 reduces tissue damage and oxidative stress caused by exhaustive exercise. Int J Med Sci 13(2):147–153

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Srikuea R, Hirunsai M (1985) Effects of intramuscular administration of 1alpha, 25(OH)2D3 during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis. J Appl Physiol 120(12):1381–1393

    Google Scholar 

  82. Barker T, Henriksen VT, Martins TB, Hill HR, Kjeldsberg CR, Schneider ED et al (2013) Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury. Nutrients 5(4):1253–1275

    CAS  PubMed  PubMed Central  Google Scholar 

  83. Barker T, Martins TB, Hill HR, Kjeldsberg CR, Dixon BM, Schneider ED et al (2014) Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans. Cytokine 65(2):134–137

    CAS  PubMed  Google Scholar 

  84. Pojednic RM, Ceglia L, Lichtenstein AH, Dawson-Hughes B, Fielding RA (2015) Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle. Endocrine 49(2):512–520

    CAS  PubMed  Google Scholar 

  85. Barker T, Schneider ED, Dixon BM, Henriksen VT, Weaver LK (2013) Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise. Nutr Metab (Lond). 10(1):69

    PubMed  PubMed Central  Google Scholar 

  86. Buitrago C, Vazquez G, De Boland AR, Boland RL (2000) Activation of Src kinase in skeletal muscle cells by 1, 1,25-(OH(2))-vitamin D(3) correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction. J Cell Biochem 79(2):274–281

    CAS  PubMed  Google Scholar 

  87. Sandgren ME, Bronnegard M, DeLuca HF (1991) Tissue distribution of the 1,25-dihydroxyvitamin D3 receptor in the male rat. Biochem Biophys Res Commun 181(2):611–616

    CAS  PubMed  Google Scholar 

  88. Roh YH, Hong SW, Chung SW, Lee YS (2019) Altered gene and protein expressions of vitamin D receptor in skeletal muscle in sarcopenic patients who sustained distal radius fractures. J Bone Miner Metab. https://doi.org/10.1007/s00774-019-00995-0

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, NSW, Australia

    Christian M. Girgis

  2. Department of Diabetes and Endocrinology, Royal North Shore Hospital, Sydney, NSW, Australia

    Christian M. Girgis

  3. University of Sydney, Sydney, NSW, Australia

    Christian M. Girgis

Authors
  1. Christian M. Girgis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christian M. Girgis.

Ethics declarations

Conflict of interest

Christian M. Girgis declares that he has no conflict of interest to disclose.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Girgis, C.M. Vitamin D and Skeletal Muscle: Emerging Roles in Development, Anabolism and Repair. Calcif Tissue Int 106, 47–57 (2020). https://doi.org/10.1007/s00223-019-00583-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00223-019-00583-4

Keywords

Search

Navigation