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Advances in Probiotic Regulation of Bone and Mineral Metabolism

Calcified Tissue International volume 102, pages 480–488 (2018)Cite this article

Abstract

Probiotics have been consumed by humans for thousands of years because they are beneficial for long-term storage of foods and promote the health of their host. Ingested probiotics reside in the gastrointestinal tract where they have many effects including modifying the microbiota composition, intestinal barrier function, and the immune system which result in systemic benefits to the host, including bone health. Probiotics benefit bone growth, density, and structure under conditions of dysbiosis, intestinal permeability, and inflammation (recognized mediators of bone loss and osteoporosis). It is likely that multiple mechanisms are involved in mediating probiotic signals from the gut to the bone. Studies indicate a role for the microbiota (composition and activity), intestinal barrier function, and immune cells in the signaling process. These mechanisms are not mutually exclusive, but rather, may synergize to provide benefits to the skeletal system of the host and serve as a starting point for investigation. Given that probiotics hold great promise for supporting bone health and are generally regarded as safe, future studies identifying mechanisms are warranted.

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Acknowledgements

The authors would like to acknowledge funding from the National Institute of Health, Grants RO1 DK101050 and RO1 AT007695.

Funding

This review was supported by NIH grants (RO1 DK101050 and RO1 AT007695) to LRM and NP.

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Authors and Affiliations

  1. Department of Physiology, Michigan State University, East Lansing, MI, USA

    Laura R. McCabe & Narayanan Parameswaran

  2. Department of Radiology, Michigan State University, East Lansing, MI, USA

    Laura R. McCabe

  3. Biomedical Imaging Research Center, Michigan State University, East Lansing, MI, USA

    Laura R. McCabe

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  1. Laura R. McCabe
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  2. Narayanan Parameswaran
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Correspondence to Laura R. McCabe or Narayanan Parameswaran.

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LRM and NP have no conflict of interest.

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McCabe, L.R., Parameswaran, N. Advances in Probiotic Regulation of Bone and Mineral Metabolism. Calcif Tissue Int 102, 480–488 (2018). https://doi.org/10.1007/s00223-018-0403-7

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Keywords

  • Probiotic
  • Microbiota
  • Osteoporosis
  • Lactobacillus
  • Intestine
  • Bone
  • Inflammation
  • Barrier
  • Permeability
  • Colon