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Gut Microbiota and IGF-1

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Abstract

Microbiota and their hosts have coevolved for millions of years. Microbiota are not only critical for optimal development of the host under normal physiological growth, but also important to ensure proper host development during nutrient scarcity or disease conditions. A large body of research has begun to detail the mechanism(s) of how microbiota cooperate with the host to maintain optimal health status. One crucial host pathway recently demonstrated to be modulated by microbiota is that of the growth factor insulin like growth factor 1 (IGF-1). Gut microbiota are capable of dynamically modulating circulating IGF-1 in the host, with the majority of data suggesting that microbiota induce host IGF-1 synthesis to influence growth. Microbiota-derived metabolites such as short chain fatty acids are sufficient to induce IGF-1. Whether microbiota induction of IGF-1 is mediated by the difference in growth hormone expression or the host sensitivity to growth hormone is still under investigation. This review summarizes the current data detailing the interaction between gut microbiota, IGF-1 and host development.

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Funding

This work was supported by NIH Grants AG046257 from the NIA, AR062590 from NIAMS, the Rheumatology Research Foundation and a Faculty Career Development Award from the Brigham and Women’s Hospital.

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Authors and Affiliations

  1. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 60 Fenwood Road, BTM 6022, Boston, MA, 02115, USA

    Jing Yan & Julia F. Charles

  2. Department of Orthopedics, Brigham and Women’s Hospital, Boston, MA, 02115, USA

    Julia F. Charles

  3. Harvard Medical School, Boston, MA, 02115, USA

    Jing Yan & Julia F. Charles

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Correspondence to Jing Yan.

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Neither Dr. Jing Yan nor Dr. Julia Charles have anything to disclose.

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Yan, J., Charles, J.F. Gut Microbiota and IGF-1. Calcif Tissue Int 102, 406–414 (2018). https://doi.org/10.1007/s00223-018-0395-3

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