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Calcified Tissue International

, Volume 102, Issue 5, pp 522–532 | Cite as

The Role of Autoantibodies in Bone Metabolism and Bone Loss

  • Barbara Hauser
  • Ulrike Harre
Review

Abstract

Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players of bone homeostasis, in particular osteoclasts. Clinical and pre-clinical studies provide insight into the function of autoantibodies related to Rheumatoid Arthritis (rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies) and their inflammation-independent interaction with bone cells. Furthermore, we summarize the current knowledge about neutralizing antibodies to the antiresorptive protein osteoprotegerin, which have been described in patients with Coeliac Disease, Rheumatoid Arthritis, and Spondyloarthritis.

Keywords

Autoantibodies Bone loss Rheumatoid arthritis Osteoprotegerin ACPA Osteoclast 

Notes

Acknowledgements

BH is supported by an Arthritis Research UK Clinical PhD studentship award. UH is supported by the Deutsche Forschungsgemeinschaft, IMI-BTCure, and the Elsbeth-Bonhoff Stiftung.

Conflict of interest

Barbara Hauser and Ulrike Harre declare that they have no conflicts of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular MedicineUniversity of EdinburghEdinburghUK
  2. 2.Department of Internal Medicine 3 – Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum ErlangenErlangenGermany

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