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In Type-2 Diabetes Subjects Trabecular Bone Score is Better Associated with Carotid Intima-Media Thickness than BMD

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Abstract

Literature data reported that in elderly subjects, carotid intima-media thickness (IMT) was negatively associated with bone mineral density (BMD). Paradoxically, type-2 diabetes (T2DM) patients, despite having higher BMD, present an increased risk of fragility fractures and cardiovascular complications. Some studies have reported trabecular bone score (TBS), an index of trabecular bone quality, as possibly being reduced in T2DM. This study aimed to evaluate whether in T2DM subjects TBS was better associated with IMT with respect to BMD. In 131 consecutive T2DM subjects (55 men and 76 women; mean age: 60.0 ± 7.3 years) and 265 consecutive non-T2DM subjects (107 men and 158 women; mean age: 58.9 ± 7.8 years) we measured carotid IMT by high-resolution ultrasonography and BMD at lumbar spine (LS-BMD), at femoral neck FN-BMD and total hip TH-BMD; TBS was calculated using TBS iNsight software. LS-BMD, FN-BMD, and TH-BMD were all significantly higher in T2DM than in non-T2DM subjects, whereas TBS was significantly lower in T2DM subjects than in controls and inversely correlated with diabetes duration. In T2DM subjects multiple regression analysis showed that IMT was positively associated with age (b = 0.017; p < 0.001) and inversely associated with TBS (b = −0.473; p = 0.038). In non-T2DM subjects, only age was positively associated with IMT. To sum up, T2DM subjects present higher values of BMD and lower values of TBS with respect to non-diabetic controls. Moreover, in T2DM subjects TBS was found to be independently associated with carotid IMT. These findings suggest that TBS may not only capture bone fragility-related factors, but also some information associated with greater risk of developing cardiovascular diseases.

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Authors and Affiliations

  1. Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100, Siena, Italy

    Carla Caffarelli, Amalia Giambelluca, Viola Ghini, Valentina Francolini, Maria Dea Tomai Pitinca, Ranuccio Nuti & Stefano Gonnelli

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  1. Carla Caffarelli
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  2. Amalia Giambelluca
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  3. Viola Ghini
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  4. Valentina Francolini
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  5. Maria Dea Tomai Pitinca
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  6. Ranuccio Nuti
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  7. Stefano Gonnelli
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Correspondence to Stefano Gonnelli.

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Conflict of interest

C. Caffarelli, A. Giambelluca, V. Ghini, V. Francolini, M. D. Tomai Pitinca, R. Nuti, and S. Gonnelli declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

The study was conducted in accordance with the ethics principles of the Declaration of Helsinki and was approved by the Ethics Committee of Siena University Hospital.

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Caffarelli, C., Giambelluca, A., Ghini, V. et al. In Type-2 Diabetes Subjects Trabecular Bone Score is Better Associated with Carotid Intima-Media Thickness than BMD. Calcif Tissue Int 101, 404–411 (2017). https://doi.org/10.1007/s00223-017-0297-9

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  • DOI: https://doi.org/10.1007/s00223-017-0297-9

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