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High Prevalence of Osteoporosis in Men with Distal Radius Fracture: A Cross-Sectional Study of 233 Men

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Abstract

Distal radius fracture is an early indicator of osteoporosis, yet little is known about men with this fracture and osteoporosis prevalence. The purpose of this cross-sectional, controlled study was to evaluate bone mineral density (BMD) in men, from working age to the elderly, with distal radius fracture. Recruitment was as follows: men who fractured during 1999–2000 were evaluated retrospectively in 2003 and men who fractured during 2003–2007 were followed prospectively for one year post-fracture. A total of 233 patients, response rate 40 %, were enrolled and compared with 643 controls. Fractures from all degrees of trauma were included. BMD was measured at femoral neck, total hip, and lumbar spine. Mean age at fracture was 52 years (21–88 years). Men aged 40–64 years had 5.4–6.7 % lower BMD at all sites compared to controls (p = 0.001) and in >65 years BMD was lower by 10.7–13.8 % (p < 0.001), while not significant at <40 years (1.4–2.8 %; p = 0.228–0.487). Osteoporosis was more prevalent at all ages (20–39 years: 8.5 vs 1.5 %; 40–64 years: 16.8 vs 5.1 %; >65 years: 23.3 vs 8.3 %) BMD did not differ with trauma level. Already from age 40, men with a distal radius fracture had lower BMD, the difference becoming more pronounced with increasing age. Also, the prevalence of osteoporosis was higher, surprisingly even in the youngest age group.

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Acknowledgments

This work was supported by grants from the Swedish Research Council (K2012-52X-14691-10-3), FAS (2007-2125), Greta and Johan Kock Foundation, A. Påhlsson Foundation, A. Osterlund Foundation, the H Järnhardt foundation, King Gustav V and Queen Victoria Foundation, The Swedish Rheumatism Association, Skåne University Hospital Research Fund, Research and Development Council of Region Skåne, Sweden; Commission of the European Communities Fifth Framework Programme ‘Quality of Life and Management of Living Resources’ Grant QLK6-CT-2001-00258.

Author’s Contribution

Lisa Egund and Fiona McGuigan were responsible for the statistical analysis and interpretation of data and Lisa Egund prepared the first draft of this paper. Karin Önnby designed the study and with Aleksander Giwercman was responsible for the acquisition of data. Kristina Akesson designed the study and is guarantor. All authors revised the paper critically for intellectual content and approved the final version. All authors agree to be accountable for the work and to ensure that any questions relating to the accuracy and integrity of the paper are investigated and properly resolved.

Funding

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Science Malmö, Lund University, Lund, Sweden

    Lisa Egund, Fiona McGuigan, Karin Önnby & Kristina Akesson

  2. Department of Orthopedics Malmö, Skåne University Hospital, 205 02, Malmö, Sweden

    Lisa Egund, Fiona McGuigan, Karin Önnby & Kristina Akesson

  3. Molecular Reproductive Medicine Research Unit, Department of Translational Medicine, Lund University, Lund, Sweden

    Aleksander Giwercman

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  1. Lisa Egund
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  2. Fiona McGuigan
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Correspondence to Kristina Akesson.

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Conflict of interest

Lisa Egund, Fiona McGuigan, Karin Önnby, Aleksander Giwercman, and Kristina Akesson declare that they have no conflict of interest.

Human and animal rights statements

All procedures performed in this study involving human participants were in concordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Egund, L., McGuigan, F., Önnby, K. et al. High Prevalence of Osteoporosis in Men with Distal Radius Fracture: A Cross-Sectional Study of 233 Men. Calcif Tissue Int 99, 250–258 (2016). https://doi.org/10.1007/s00223-016-0142-6

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  • DOI: https://doi.org/10.1007/s00223-016-0142-6

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