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Association Between Aortic Calcification and the Risk of Osteoporosis in a Chinese Cohort: The Chongqing Osteoporosis Study

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Abstract

The aim of this study was to examine the relationship between aortic calcification (AC) and the risk of osteoporosis for a community of residents in China. We conducted a 5-year prospective study on 1,729 Chinese elderly subjects. An AC scale (ACS) was determined semiquantitatively from baseline lateral radiographs of the lumbar spine. Dual-energy X-ray absorptiometry was used to determine bone mineral density (BMD). Only subjects who completed the study were included in the final analysis; 432 subjects (25.0 %) developed osteoporosis. The BMD of vertebrae, femoral neck, and the total hip in the Q4 quartile of the ACS (ACS > 6) was lower when compared with the Q1 quartile (ACS = 0, p < 0.05). Cox proportional hazards model analysis showed that ACS (Q4), BMD, CTX, current smoking, and daily drinking were associated with increased risk of osteoporosis. A higher ACS was associated with an increased risk of osteoporosis in both women and men. The present study found that AC carried a higher risk of osteoporosis.

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Authors and Affiliations

  1. Department of Orthopedics, The Orthopedic Surgery Center of Chinese PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, People’s Republic of China

    Rui Zhou & Jianzhong Xu

  2. Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

    Huadong Zhou, Min Cui & Yanjiang Wang

  3. Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry & Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

    Jun Tan & Darrell Sawmiller

Authors
  1. Rui Zhou
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  2. Huadong Zhou
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  3. Min Cui
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  4. Yanjiang Wang
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  5. Jun Tan
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  6. Darrell Sawmiller
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  7. Jianzhong Xu
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Correspondence to Jianzhong Xu.

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The authors have stated that they have no conflict of interest.

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Zhou, R., Zhou, H., Cui, M. et al. Association Between Aortic Calcification and the Risk of Osteoporosis in a Chinese Cohort: The Chongqing Osteoporosis Study. Calcif Tissue Int 93, 419–425 (2013). https://doi.org/10.1007/s00223-013-9776-9

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  • DOI: https://doi.org/10.1007/s00223-013-9776-9

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