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Longitudinal Changes of Bone Ultrasound Measurements in Healthy Infants during the First Year of Life: Influence of Gender and Type of Feeding

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Abstract

There is evidence suggesting that early events in life may predispose the adult to osteoporosis. We assessed bone status by quantitative ultrasonography in healthy neonates, and we report the changes occurring during the first year of life, according to the type of early feeding. We measured the speed of sound (SOS) of the left tibia in 116 full-term infants (0–9 days of age) and in their mothers (21–42 years of age). SOS values did not correlate with gestational age of the study subjects (r = 0.08) or anthropometric measurements. The SOS measurements of the mothers did not correlate with those of their children (r = 0.01). Fifty-seven infants had SOS measurements performed at 4 and 12 months. Twenty-five infants were exclusively breast-fed, 12 received formula milk from birth, and 20 received human and formula milk. SOS measurements at 4 months were comparable with those at baseline, whereas at 12 months they were significantly higher. No effect of type of feeding was observed, indicating that SOS changes may be independent of the type of early diet.

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References

  1. Mora S, Gilsanz V (2003) Establishment of peak bone mass. Endocrinol Metab Clin North Am 32:39–63

    Article  PubMed  Google Scholar 

  2. Cooper C, Westlake S, Harvey N, Javaid K, Dennison E, Hanson M (2006) Developmental origins of osteoporotic fracture. Osteoporos Int 17:337–347

    Article  PubMed  Google Scholar 

  3. Foldes AJ, Rimon A, Keinan DD, Popovtzer MM (1995) Quantitative ultrasound of the tibia: a novel approach for assessment of bone status. Bone 17:363–367

    Article  PubMed  CAS  Google Scholar 

  4. Njeh CF, Fuerst T, Diessel E, Genant HK (2001) Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporos Int 12:1–15

    PubMed  CAS  Google Scholar 

  5. Hans D, Dargent-Molina P, Schott AM, Sebert JL, Cormier C, Kotzi PO, Delmas PD, Pouilles JM, Breart G, Meunier PJ (1996) Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet 348:511–514

    Article  PubMed  CAS  Google Scholar 

  6. Khaw KT, Reeve J, Luben R (2004) Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet 363:197–202

    Article  PubMed  Google Scholar 

  7. Lequin MH, Van der Shuis IM, Van Rijn RR, Hop WC, Van Ven Heuvel-Eibrink MM, Muinckkeizer-Schrama SM, Van Kuijk C (2002) Bone mineral assessment with tibial ultrasonography and dual-energy X-ray absorptiometry in long term survivors of acute lymphoblastic leukaemia in childhood. J Clin Densitom 5:167–173

    Article  PubMed  CAS  Google Scholar 

  8. Mora S, Viganò A, Cafarelli L, Pattarino G, Giacomet V, Gabiano C, Mignone F, Zuccotti G (2009) Applicability of quantitative ultrasonography of the radius and tibia in HIV-infected children and adolescents. J Acquir Immune Defic Syndr 51:588–592

    Article  PubMed  Google Scholar 

  9. Nemet D, Dolfin T, Wolach B, Eliakim A (2001) Quantitative ultrasound measurements of bone speed of sound in premature infants. Eur J Pediatr 160:736–740

    PubMed  CAS  Google Scholar 

  10. Eliakim A, Nemet D, Friedland O, Dolfin T, Regev RH (2002) Spontaneous activity in premature infants affects bone strength. J Perinatol 22:650–652

    Article  PubMed  Google Scholar 

  11. Litmanovitz I, Dolfin T, Regev R, Arnon S, Friedland O, Shainkin-Kestenbaum R, Lis M, Eliakim A (2004) Bone turnover markers and bone strength during the first weeks of life in very low birth weight premature infants. J Perinat Med 32:58–61

    Article  PubMed  Google Scholar 

  12. Gonelli S, Montagnani A, Gennari L, Martini S, Merlotti D, Cepollaro C, Perrone S, Buonocore G, Nuti R (2004) Feasibility of quantitative ultrasound measurements on the humerus of newborn infants for the assessment of the skeletal status. Osteoporos Int 15:541–546

    Article  Google Scholar 

  13. Yiallourides M, Savoia M, May J, Emmerson AJ, Mughal MZ (2004) Tibial speed of sound in term and preterm infants. Biol Neonate 85:225–228

    Article  PubMed  CAS  Google Scholar 

  14. Ritschl E, Wehmeijer K, De Terlizzi F, Wipfler E, Cadossi R, Douma D, Urlesberger B, Muller W (2005) Assessment of skeletal development in preterm and term infants by quantitative ultrasound. Pediatr Res 58:341–346

    Article  PubMed  Google Scholar 

  15. McDevitt H, Tomlinson C, White M, Ahmed SF (2005) The assessment of bone by quantitative ultrasound in preterm and term neonates. Arch Dis Child Fetal Neonatal Ed 90:F341–F342

    Article  PubMed  CAS  Google Scholar 

  16. Liao XP, Zhang WL, He J, Sun JH, Huang P (2005) Bone measurements of infants in the first 3 months of life by quantitative ultrasound: the influence of gestational age, season, and postnatal age. Pediatr Radiol 35:847–853

    Article  PubMed  Google Scholar 

  17. Tomlinson C, McDevitt H, White MP, Ahmed SF (2006) Longitudinal changes in bone health as assessed by the speed of sound in very low birth weight preterm infants. J Pediatr 148:450–455

    Article  PubMed  CAS  Google Scholar 

  18. Roggero P, Giannì ML, Orsi A, Piemontese P, Amato O, Mora S, Puricelli V, Mosca F (2007) Postnatal “speed of sound” decline in preterm infants: an exploratory study. J Pediatr Gastroenterol Nutr 45:615–617

    Article  PubMed  Google Scholar 

  19. Fewtrell MS, Loh KL, Chomtho S, Kennedy K, Hawdon J, Khakoo A (2008) Quantitative ultrasound (QUS): a useful tool for monitoring bone health in preterm infants? Acta Paediatr 97:1625–1630

    Article  PubMed  CAS  Google Scholar 

  20. Koo WWK, Bajaj M, Mosley M, Hammami M (2008) Quantitative bone US measurements in neonates and their mothers. Pediatr Radiol 38:1323–1329

    Article  PubMed  Google Scholar 

  21. Teitelbaum JE, Rodriguez RJ, Ashmeade TL, Yaniv I, Osuntokun BO, Hudome S, Fanaroff A (2006) Quantitative ultrasound in the evaluation of bone status in premature and full-term infants. J Clin Densitom 9:358–362

    Article  PubMed  Google Scholar 

  22. Chan GM, Armstrong C, Moyer-Mileur L, Hoff C (2008) Growth and bone mineralization in children born prematurely. J Perinatol 28:619–623

    Article  PubMed  CAS  Google Scholar 

  23. Beltrand J, Alison M, Nicolescu R, Verkauskiene R, Deghmoun S, Sibony O, Sebag G, Lévy-Marchal C (2008) Bone mineral content at birth is determined both by birth weight and fetal growth pattern. Pediatr Res 64:86–90

    Article  PubMed  Google Scholar 

  24. De Schepper J, Cools F, Vandenplas Y, Louis O (2005) Whole body bone mineral content is similar at discharge from the hospital in premature infants receiving fortified breast milk or preterm formula. J Pediatr Gastroenterol Nutr 41:230–234

    Article  PubMed  Google Scholar 

  25. Baroncelli GI (2008) Quantitative ultrasound methods to assess bone mineral status in children: technical characteristics, performance, and clinical application. Pediatr Res 63:220–228

    Article  PubMed  Google Scholar 

  26. Harvey NC, Javaid MK, Poole JR, Taylor P, Robinson SM, Inskip HM, Godfrey KM, Cooper C, Dennison EM, Southampton Women’s Survey Study Group (2008) Paternal skeletal size predicts intrauterine bone mineral accrual. J Clin Endocrinol Metab 93:1676–1681

    Article  PubMed  CAS  Google Scholar 

  27. Godfrey K, Walker-Bone K, Robinson S, Taylor P, Shore S, Wheeler T, Cooper C (2001) Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy. J Bone Miner Res 16:1694–1703

    Article  PubMed  CAS  Google Scholar 

  28. Seeman E, Tsalamandris C, Formica C, Hopper JL, McKay J (1994) Reduced femoral neck bone density in the daughters of women with hip fractures: the role of low peak bone density in the pathogenesis of osteoporosis. J Bone Miner Res 9:739–743

    Article  PubMed  CAS  Google Scholar 

  29. Jouanny P, Guillemin F, Kuntz C, Jeandel C, Pourel J (1995) Environmental and genetic factors affecting bone mass: similarity of bone density among members of healthy families. Arthritis Rheum 38:61–67

    Article  PubMed  CAS  Google Scholar 

  30. François S, Benmalek A, Guaydier-Souquières G, Sabatier JP, Marcelli C (1999) Heritability of bone mineral density. Rev Rhum Engl Ed 66:146–151

    PubMed  Google Scholar 

  31. Abou Samra H, Stevens D, Binkley T, Specker B (2009) Determinants of bone mass and size in 7-year-old former term, late-preterm, and preterm boys. Osteoporos Int 20:1903–1910

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported in part by the grant Bando nazionale AIDS 2009, convenzione numero 40H1.

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Authors and Affiliations

  1. Department of Pediatrics, L. Sacco Hospital, University of Milan, 20157, Milan, Italy

    Gianvincenzo Zuccotti, Alessandra Viganò, Laura Cafarelli, Valentina Pivetti & Laura Pogliani

  2. Laboratory of Pediatric Endocrinology, BoNetwork, Division of Metabolic and Cardiovascular Sciences, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy

    Maria Puzzovio & Stefano Mora

Authors
  1. Gianvincenzo Zuccotti
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  2. Alessandra Viganò
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  3. Laura Cafarelli
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  4. Valentina Pivetti
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  5. Laura Pogliani
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  6. Maria Puzzovio
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  7. Stefano Mora
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Correspondence to Stefano Mora.

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The authors have stated that they have no conflict of interest.

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Zuccotti, G., Viganò, A., Cafarelli, L. et al. Longitudinal Changes of Bone Ultrasound Measurements in Healthy Infants during the First Year of Life: Influence of Gender and Type of Feeding. Calcif Tissue Int 89, 312–317 (2011). https://doi.org/10.1007/s00223-011-9520-2

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  • DOI: https://doi.org/10.1007/s00223-011-9520-2

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