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The Effects of Strontium Ranelate in Asian Women with Postmenopausal Osteoporosis

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An Erratum to this article was published on 11 March 2009

Abstract

The aim of this study was to assess the efficacy and safety of strontium ranelate in the treatment of postmenopausal women with osteoporosis in Taiwan. In this 12-month multicenter, randomized, double-blind, placebo-controlled study, 125 women with osteoporosis were randomly given either strontium ranelate 2 g daily or placebo. Lumbar spine, femoral neck, and total-hip bone mineral density (BMD) and biochemical markers of bone turnover were measured; adverse events and tolerability were recorded and assessed. Subjects treated with strontium ranelate showed significant increases in BMD of 5.9% at the lumbar spine, 2.6% at the femoral neck, and 2.7% at the total hip, while the placebo group exhibited no significant change at 12 months. Serum level of a formation marker (bone-specific alkaline phosphatase) was also significantly increased at 6 and 12 months. Thus, although the sample size and the treatment duration of this study could not show its effect of reducing osteoprotic fractures, strontium ranelate showed bone protection effects by increasing BMD and concentrations of a bone formation marker. Safety assessment revealed adverse events were mild and not significantly different from placebo.

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References

  1. Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761–1767

    Article  PubMed  Google Scholar 

  2. Melton LJ III (1995) How many women have osteoporosis now? J Bone Miner Res 10:175–177

    PubMed  Google Scholar 

  3. Tsai KS, Tai TY (1997) Epidemiology of osteoporosis in Taiwan. Osteoporos Int 7(Suppl 3):S96–S98

    PubMed  Google Scholar 

  4. Yang TS, Chen YR, Chen YJ, Chang CY, Ng HT (2004) Osteoporosis: prevalence in Taiwanese women. Osteoporos Int 15:345–347

    Article  PubMed  Google Scholar 

  5. Cooper C (1997) The crippling consequences of fractures and their impact on quality of life. Am J Med 103:12S–19S

    Article  PubMed  CAS  Google Scholar 

  6. Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878–882

    Article  PubMed  CAS  Google Scholar 

  7. Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, Bauer DC, Genant HK, Haskell WL, Marcus R, Ott SM, Torner JC, Quandt SA, Reiss TF, Ensrud KE (1996) Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 348:1535–1541

    CAS  Google Scholar 

  8. Harris ST, Watts NB, Genant HK, McKeever CD, Hangartner T, Keller M, Chesnut CH III, Brown J, Eriksen EF, Hoseyni MS, Axelrod DW, Miller PD (1999) Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. JAMA 282:1344–1352

    Article  PubMed  CAS  Google Scholar 

  9. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH (2001) Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434–1441

    Article  PubMed  CAS  Google Scholar 

  10. Eastell R (1998) Treatment of postmenopausal osteoporosis. N Engl J Med 338:736–746

    Article  PubMed  CAS  Google Scholar 

  11. Chesnut CH III, Silverman S, Andriano K, Genant H, Gimona A, Harris S, Kiel D, LeBoff M, Maricic M, Miller P, Moniz C, Peacock M, Richardson P, Watts N, Baylink D (2000) A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the Prevent Recurrence of Osteoporotic Fractures Study. PROOF Study Group. Am J Med 109:267–276

    CAS  Google Scholar 

  12. Cranney A, Guyatt G, Griffith L, Wells G, Tugwell P, Rosen C, Osteoporosis Methodology Group, Osteoporosis Research Advisory Group (2002) Meta-analyses of therapies for postmenopausal osteoporosis IX: summary of meta-analyses of therapies for postmenopausal osteoporosis. Endocr Rev 23:570–578

    Article  PubMed  CAS  Google Scholar 

  13. Hwang JS, Tu ST, Yang TS, Chen JF, Wang CJ, Tsai KS (2006) Teriparatide vs calcitonin in the treatment of Asian postmenopausal women with established osteoporosis. Osteoporos Int 17:373–378

    Article  PubMed  CAS  Google Scholar 

  14. Yen ML, Yen BL, Jang MH, Hsu SH, Cheng WC, Tsai KS (2000) Effects of alendronate on osteopenic postmenopausal Chinese women. Bone 27:681–685

    Article  PubMed  CAS  Google Scholar 

  15. Burlet N, Reginster JY (2006) Strontium ranelate: the first dual acting treatment for postmenopausal osteoporosis. Clin Orthop Relat Res 443:55–60

    Article  PubMed  Google Scholar 

  16. Marie PJ, Ammann P, Boivin G, Rey C (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69:121–129

    Article  PubMed  CAS  Google Scholar 

  17. Reginster JY, Seeman E, De Vernejoul MC, Adami S, Compston J, Phenekos C, Devogelaer JP, Curiel MD, Sawicki A, Goemaere S, Sorensen OH, Felsenberg D, Meunier PJ (2005) Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90:2816–2822

    Article  PubMed  CAS  Google Scholar 

  18. Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK, Reginster JY (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350:459–468

    Article  PubMed  CAS  Google Scholar 

  19. Genant HK, Wu CY, van KC, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137–1148

    Article  PubMed  CAS  Google Scholar 

  20. Barbara A, Delannoy P, Denis BG, Marie PJ (2004) Normal matrix mineralization induced by strontium ranelate in MC3T3–E1 osteogenic cells. Metabolism 53:532–537

    Article  PubMed  CAS  Google Scholar 

  21. Canalis E, Hott M, Deloffre P, Tsouderos Y, Marie PJ (1996) The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone 18:517–523

    Article  PubMed  CAS  Google Scholar 

  22. Baron R, Tsouderos Y (2002) In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 450:11–17

    Article  PubMed  CAS  Google Scholar 

  23. Takahashi N, Sasaki T, Tsouderos Y, Suda T (2003) S12911-2 inhibits osteoclastic bone resorption in vitro. J Bone Miner Res 18:1082–1087

    Article  PubMed  CAS  Google Scholar 

  24. Buehler J, Chappuis P, Saffar JL, Tsouderos Y, Vignery A (2001) Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone 29:176–179

    Article  PubMed  CAS  Google Scholar 

  25. Delannoy P, Bazot D, Marie PJ (2002) Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice. Metabolism 51:906–911

    Article  PubMed  CAS  Google Scholar 

  26. Ammann P, Shen V, Robin B, Mauras Y, Bonjour JP, Rizzoli R (2004) Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats [erratum appears in J Bone Miner Res 2005;20:548]. J Bone Miner Res 19:2012–2020

    Google Scholar 

  27. Pors NS (2004) The biological role of strontium. Bone 35:583–588

    Article  CAS  Google Scholar 

  28. Meunier PJ, Slosman DO, Delmas PD, Sebert JL, Brandi ML, Albanese C, Lorenc R, Pors-Nielsen S, De Vernejoul MC, Roces A, Reginster JY (2002) Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis—a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 87:2060–2066

    Article  PubMed  CAS  Google Scholar 

  29. Ortolani S, Vai S (2006) Strontium ranelate: an increased bone quality leading to vertebral antifracture efficacy at all stages. Bone 38(Suppl 1):19–22

    Article  PubMed  CAS  Google Scholar 

  30. Nielsen SP, Slosman D, Sorensen OH, Basse-Cathalinat B, De CP, Roux CR, Meunier PJ (1999) Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry. J Clin Densitom 2:371–379

    Article  PubMed  CAS  Google Scholar 

  31. Blake GM, Fogelman I (2007) Effect of bone strontium on BMD measurements. J Clin Densitom 10:34–38

    Article  PubMed  Google Scholar 

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Acknowledgments

This project was funded by Servier, Inc., as a phase IIIB clinical trial for registration in Taiwan. We thank the clinical staff at all study sites for their important contributions to the study.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Chlayi, Kaohsiung, Taiwan, ROC

    J. S. Hwang, J. F. Chen & C. Ho

  2. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC

    T. S. Yang

  3. Departments of Internal Medicine and Family Medicine, National Cheng Kung University, Medical Center, Tainan, Taiwan, ROC

    D. J. Wu & C. H. Wu

  4. Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC

    K. S. Tsai

  5. Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, Taiwan, ROC

    S. L. Su & S. T. Tu

  6. Department of Radiology, Chang Gung Memorial Hospital, Linkou, Chang Gung University, Taipei, Taiwan, ROC

    C. J. Wang

Authors
  1. J. S. Hwang
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  2. J. F. Chen
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  3. T. S. Yang
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  4. D. J. Wu
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  5. K. S. Tsai
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  6. C. Ho
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  7. C. H. Wu
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  8. S. L. Su
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  9. C. J. Wang
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  10. S. T. Tu
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Corresponding author

Correspondence to S. T. Tu.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00223-009-9233-y

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Hwang, J.S., Chen, J.F., Yang, T.S. et al. The Effects of Strontium Ranelate in Asian Women with Postmenopausal Osteoporosis. Calcif Tissue Int 83, 308–314 (2008). https://doi.org/10.1007/s00223-008-9180-z

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  • DOI: https://doi.org/10.1007/s00223-008-9180-z

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