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Relationship between Vitamin D Metabolites and Bone Mineral Density in Young Males: A Cross-Sectional and Longitudinal Study

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Abstract

The purpose of this study was to investigate the association between vitamin D analogs and peak bone mineral density (BMD, g/cm2) in young men. The cohort consisted of 78 healthy young males with a mean age of 22.6 years at baseline. BMD of the total body, hip, and spine and lean body mass were measured at baseline and at follow-up 2 years later. Blood samples were assayed for 25−hydroxyvitamin D2 (25OHD2), 25-hydroxyvitamin D3 (25OHD3), and 25-hydroxyvitamin D (25OHD) at baseline using high-performance liquid chromatography. Levels of 25OHD3 significantly correlated to BMD at all sites and to lean body mass (r = 0.23–0.35, P < 0.05). In contrast, levels of 25OHD2 significantly negatively correlated with BMD of the total body (r = −0.28, P = 0.01) and spine (r = −0.27, P = 0.02). BMD was then adjusted for the influence of age, body weight, body height, and physical activity (hours/week). Level of 25OHD3 was then found to be an independent predictor of BMD of the total body (beta = 0.24, P = 0.03) and spine (beta = 0.25, P = 0.03), while level of 25OHD2 was an independent negative predictor at the same sites (beta = −0.23 for both, P = 0.03). There was a negative association between levels of 25OHD3 and 25OHD2 (r = −0.31, P = 0.006). In summary, our novel results suggest an inverse relationship between 25OHD3 and 25OHD2 and an opposite relationship of these vitamin D analogs to BMD in young men.

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Acknowledgments

The present study was supported by grants from the Länsförsäkringar insurance company (project P4/01) and from the Swedish National Center for Research in Sports (project 112/01).

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Authors and Affiliations

  1. Sports Medicine, Department of Surgical and Perioperative Science, Umeå University, S-901 85, Umeå, Sweden

    M. Högström, A. Nordström & P. Nordström

  2. Department of Community Medicine and Rehabilitation Medicine, Umeå University, S-901 85, Umeå, Sweden

    A. Nordström

  3. Department of Public Health and Clinical Medicine, Umeå University, S-901 85, Umeå, Sweden

    P. Nordström

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  1. M. Högström
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Correspondence to P. Nordström.

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Högström, M., Nordström, A. & Nordström, P. Relationship between Vitamin D Metabolites and Bone Mineral Density in Young Males: A Cross-Sectional and Longitudinal Study. Calcif Tissue Int 79, 95–101 (2006). https://doi.org/10.1007/s00223-006-0049-8

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  • DOI: https://doi.org/10.1007/s00223-006-0049-8

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