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Bone Mineral Changes in Acute Metabolic Acidosis due to Acute Gastroenteritis

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Abstract

We studied bone mineral metabolism changes complicated by acute gastroenteritis in a clinical acute metabolic acidosis milieu where we observed hypercalcemia, hypercalciuria, and elevated urinary hydroxyproline excretion. Serum magnesium and plasma osteocalcin, alkaline phosphatase, and IGF-1 levels were decreased. No significant changes in serum inorganic phosphate and plasma PTH, calcitonin, or 25-hydroxy vitamin D3 levels were detected. All abnormalities disappeared with the correction of acidosis. Observed hypercalcemia seems to be the result of increased calcium efflux from bone due to metabolic acidosis-induced catabolism of type 1 collagen and decreased osteoblastic activity. This study provides data regarding acute metabolic acidosis-induced changes in noninvasive parameters of bone modeling, assessed for the first time in humans.

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Authors and Affiliations

  1. Pediatric Intensive Care Unit, Faculty of Medicine, Çukurova University, Adana, Turkey

    Dincer Yildizdas

  2. Division of Pediatric Endocrinology and Metabolism, Faculty of Medicine, Çukurova University,, Adana, Turkey

    A. Kemal Topaloglu, Neslihan O. Mungan, Bilgin Yuksel & Guler Ozer

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  1. Dincer Yildizdas
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  2. A. Kemal Topaloglu
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  3. Neslihan O. Mungan
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  4. Bilgin Yuksel
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  5. Guler Ozer
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Correspondence to A. Kemal Topaloglu.

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Yildizdas, D., Topaloglu, A.K., Mungan, N.O. et al. Bone Mineral Changes in Acute Metabolic Acidosis due to Acute Gastroenteritis. Calcif Tissue Int 75, 380–383 (2004). https://doi.org/10.1007/s00223-004-0252-4

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  • DOI: https://doi.org/10.1007/s00223-004-0252-4

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