Abstract
In the space of a few weeks, four articles appeared in the The Lancet and JAMA suggesting that using 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) is associated with increased bone mineral density (BMD) [1] and a reduced fracture risk [2-4]. The stimulus for these case-control studies came from reports that the statins have unexpected effects on bone, increasing bone formation in rodents [5]. These observations offered a new insight into the potential importance of the cholesterol synthesis pathway in bone turnover and future therapeutic opportunities.
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apd: 27 July 2001
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Edwards, C., Russell, R. & Spector, T. Statins and Bone: Myth or Reality?. Calcif Tissue Int 69, 63–66 (2001). https://doi.org/10.1007/s00223-001-2017-7
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DOI: https://doi.org/10.1007/s00223-001-2017-7