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MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage

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Abstract

Spontaneous subarachnoid hemorrhage (SAH) accounts for approximately 5% of all cases of stroke. SAH is correlated with elevated rates of mortality and disability. Despite significant advancements in comprehending the pathogenesis and surgical management, efficacious clinical interventions remain restricted, and the prognosis is yet to be enhanced. MicroRNAs play a crucial role in various pathological processes in organisms. Revealing these regulatory processes is conducive to the development of new treatment methods. MicroRNA-124 is highly expressed in the nervous system and has significant research value for SAH. This study aims to explore the role of miR-124 in the early post-SAH period on neural function and verify whether it is involved in the pathological and physiological processes of SAH. In this study, we used methods such as comparing the expression levels of miR-124 in cerebrospinal fluid, establishing a rat SAH model, and a mouse embryonic primary neuron hemoglobin stimulation model to verify the downstream proteins of miR-124 in SAH. Through transfection techniques, we adjusted the expression of this small RNA in Vitro and in Vivo models using miR-124 inhibitor and mimic in the primary neuron hemoglobin stimulation model and rat SAH model, and observed the phenotype. Finally, by consulting the literature and verifying in Vivo and in Vitro methods, AK4 and downstream molecule ATF3 were identified as downstream targets of miR-124.

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Acknowledgements

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Funding

This work was funded by the National Natural Science Foundation of China (No. 81971133).

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  1. Wei Jiang, Qingge Jia and Hongxin Ma contributed equally to this paper.

Authors and Affiliations

  1. Department of Neurosurgery, General Hospital of Northern Theater Command, Wenhua Rd. No.83, Shenyang, 110000, Liaoning, China

    Wei Jiang, Hongxin Ma, Song Han, Shijun Bi, Kunyuan Zhu, Ligang Chen & Guobiao Liang

  2. Department of Reproductive Endocrinology, Xi’an International Medical Center Hospital, Northwest University, Xi’an, China

    Qingge Jia

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  1. Wei Jiang
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Contributions

GBL and LGC contributed to the conception of the study and perform constructive discussions; JW performed the data collection and analysis; JW, QGJ and HXM wrote the manuscript; SH, KYZ and SJB contributed to data analysis and manuscript preparation.

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Correspondence to Ligang Chen or Guobiao Liang.

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All authors declare no conflict of interest.

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Informed consent was obtained from all patients. This study was ethically approved by the Northern Theater General Hospital Ethics Committee (approve number: 2020–024).

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Communicated by Sreedharan Sajikumar.

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221_2023_6682_MOESM1_ESM.tif

Supplementary file1 (TIF 13688 KB) Supplementary Figure 1. (A) Expression of AK4 and ATF3 in miR-124 mimic neurons. (B) Biological Process GO enrichment map of down-regulated proteins in SAH vs non-SAH. (C) Molecular Function GO enrichment map of down-regulated protein molecular function in down-regulated proteins in SAH vs non-SAH.

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Jiang, W., Jia, Q., Ma, H. et al. MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage. Exp Brain Res 242, 33–45 (2024). https://doi.org/10.1007/s00221-023-06682-x

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