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Corticospinal and spinal adaptations following lower limb motor skill training: a meta-analysis with best evidence synthesis

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Abstract

Motor skill training alters the human nervous system; however, lower limb motor tasks have been less researched compared to upper limb tasks. This meta-analysis with best evidence synthesis aimed to determine the cortical and subcortical responses that occur following lower limb motor skill training, and whether these responses are accompanied by improvements in motor performance. Following a literature search that adhered to the PRISMA guidelines, data were extracted and analysed from six studies (n = 172) for the meta-analysis, and 11 studies (n = 257) were assessed for the best evidence synthesis. Pooled data indicated that lower limb motor skill training increased motor performance, with a standardised mean difference (SMD) of 1.09 being observed. However, lower limb motor skill training had no effect on corticospinal excitability (CSE), Hoffmann’s reflex (H-reflex) or muscle compound action potential (MMAX) amplitude. The best evidence synthesis found strong evidence for improved motor performance and reduced short-interval cortical inhibition (SICI) following lower limb motor skill training, with conflicting evidence towards the modulation of CSE. Taken together, this review highlights the need for further investigation on how motor skill training performed with the lower limb musculature can modulate corticospinal responses. This will also help us to better understand whether these neuronal measures are underpinning mechanisms that support an improvement in motor performance.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Abbreviations

CI:

Confidence interval

CSE:

Corticospinal excitability

EEG:

Electroencephalogram

EMG:

Electromyography

FDI:

First dorsal interosseous

fMRI:

Functional magnetic resonance imagining

GABA:

Gamma aminobutyric acid

H-reflex:

Hoffmann reflex

ISI:

Interstimulus interval

LTP:

Long-term potentiation

M1:

Primary motor cortex

MEP:

Motor-evoked potential

MMAX :

Muscle compound action potential

SICI:

Short-interval intracortical inhibition

SMD:

Standardised mean difference

STP:

Short-term potentiation

TA:

Tibialis anterior

TMS:

Transcranial magnetic stimulation

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Authors and Affiliations

Authors

Contributions

All authors contributed to the study conception and design (AW, JSN, JH, CPM, DJK, and JT). Literature search and data extraction was performed by Alex Woodhead and Jamie Tallent. The first draft of the manuscript was written by Alex Woodhead and all authors (JSN, JH, CPM, DJK, and JT) commented on previous versions of the manuscript. All authors read and improved the final manuscript.

Corresponding author

Correspondence to Alex Woodhead.

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The authors declare no conflict of interest, financial, or otherwise.

Additional information

Communicated by Bill J Yates.

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Woodhead, A., North, J.S., Hill, J. et al. Corticospinal and spinal adaptations following lower limb motor skill training: a meta-analysis with best evidence synthesis. Exp Brain Res 241, 807–824 (2023). https://doi.org/10.1007/s00221-023-06563-3

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  • DOI: https://doi.org/10.1007/s00221-023-06563-3

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