Abstract
Dementia with Lewy body is a neurodegenerative disorder affecting both cognitive and motor domains. Motor impairment manifests predominantly as a symmetrical/mild asymmetrical parkinsonian syndrome that is only mildly responsive to Levodopa. To characterize motor dysfunction in dementia with Lewy body, we quantitatively assessed upper limb movements using a motion-capture system. Ten patients and ten healthy controls were tested while performing the hand-to-mouth movement of which speed, smoothness and accuracy features were measured. The results showed that individuals with dementia with Lewy body required a longer time to complete the task, particularly due to a prolonged duration of the adjusting phase (i.e., when approaching the target/mouth). The overall motor performance of dementia with Lewy body patients closely resembled what previously observed in patients affected by both Parkinson’s disease and ataxia while performing the same task. Moreover, the severity of parkinsonian symptoms as assessed by the UPDRS-III scale impacted on the velocity of movement alone whereas impairment of executive functions correlated with variables related to the phase of targeting the mouth. This study provides new information about upper limb motor dysfunction in dementia with Lewy body.
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References
Alberts JL, Saling M, Adler CH, Stelmach GE (2000) Disruptions in the reach-to-grasp actions of Parkinson’s patients. Exp Brain Res 134(3):353–362
Amboni M, Barone P, Hausdorff JM (2013) Cognitive contributions to gait and falls: evidence and implications. Mov Disord 28(11):1520–1533
Appollonio I, Leone M, Isella V et al (2005) The frontal assessment battery (FAB):normative values in an Italian population sample. Neurol Sci 26(2):108–116
Caimmi M, Carda S, Giovanzana C, Maini ES, Sabatini AM, Smania N, Molteni F (2008) Using kinematic analysis to evaluate constraint-induced movement therapy in chronic stroke patients. Neurorehabilit Neural Repair 22(1):31–39
Carpinella I, Cattaneo D, Ferrarin M (2014) Quantitative assessment of upper limb motor function in multiple sclerosis using an instrumented action research arm test. J Neuroeng Rehabil 11:67
Cimolin V, Beretta E, Piccinini L, Turconi AC, Locatelli F, Galli M, Strazzer S (2012) Constraint-Induced movement therapy for children with hemiplegia after traumatic brain injury: a quantitative study. J Head Trauma Rehabil 27(3):177–187. https://doi.org/10.1097/HTR.0b013e3182172276
Colloby SJ, O’Brien JT, Taylor J (2014) Pattern of cerebellar volume loss in dementia with Lewy bodies and Alzheimer’s disease: a VBM-DARTEL study. Psychiatry Res Neuroimaging 223:187–191
Corona F, Pilloni G, Arippa F, Porta M, Casula C, Cossu G, Pau M (2018a) Quantitative assessment of upper limb functional impairments in people with Parkinson’s disease. Clin Biomech 57:137–143
Corona F, Gervasoni E, Coghe G, Cocco E, Ferrarin M, Pau M, Cattaneo D (2018b) Validation of the arm profile score in assessing upper limb functional impairments in people with multiple sclerosis. Clin Biomech (Bristol, Avon) 51:45–50. https://doi.org/10.1016/j.clinbiomech.2017.11.010
Feng CJ, Mak AFT (1997) Three-dimensional motion analysis of the voluntary elbow movement in subjects with spasticity. IEEE Rehabil Eng 5(3):253–262. https://doi.org/10.1109/86.623017
Lindsay E, Storey E (2017) Cognitive changes in the spinocerebellar ataxias due to expanded polyglutamine tracts: a survey of the literature. Brain Sci 7(7):83
Mackey AH, Walt SE, Lobb GA, Stott NS (2005) Reliability of upper and lower limb three-dimensional kinematics in children with hemiplegia. Gait Posture 22(1):1–9. https://doi.org/10.1016/j.gaitpost.2004.06.002
Magni E, Binetti G, Bianchetti A, Rozzini R, Trabucchi M (1996) Mini-mental state examination: a normative study in italian elderly population. Eur J Neurol 3(3):198–202
McKeith I, Dickson DW, Lowe J et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB CONSORTIUM. Neurology 65:1863–1872
McKeith IG, Boeve BF, Dickson DW et al (2017) Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortium. Neurology 89(1):88–100
Menegoni F, Milano E, Trotti C (2009) Quantitative evaluation of functional limitation of upper limb movements in subjects affected by ataxia. Eur J Neurol 16:232–239
Morris JC (1993) The clinical dementia rating (CDR): current version and scoring rules. Neurology 43(11):2412–2414
Movement Disorder Society Task Force on Rating Scales for Parkinson’s Disease (2003) The Unified Parkinson’s Disease Rating Scale (UPDRS): status and recommendations. Mov Disord 18(7):738–750
Nakatsuka T, Imabayashi E, Matsuda H, Sakakibara R, Inaoka T, Terada H (2013) Discrimination of dementia with Lewy bodies from Alzheimer’s disease using voxel-based morphometry of white matter by statistical parametric mapping 8 plus diffeomorphic anatomic registration through exponentiated Lie algebra. Neuroradiology 55:559–566
Quintern J, Immisch I, Albrecht H, Pöllmann W, Glasauer S, Straube A (1999) Influence of visual and proprioceptive afferences on upper limb ataxia in patients with multiple sclerosis. J Neurol Sci 163:61–69
Rab G, Petuskey K, Bagley A (2002) A method for determination of upper extremity kinematics. Gait Posture 15(2):113–119
Rigoldi C, Molteni E, Rozbaczylo C, Morante M, Albertini G, Bianchi AM, Galli M (2012) Movement analysis and EEG recordings in children with hemiplegic cerebral palsy. Exp Brain Res 223(4):517–524. https://doi.org/10.1007/s00221-012-3278-2
Seidel K, Bouzrou M, Heidemann N et al (2017) Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies. Ann Neurol 81:898–903
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Fadda, L., Corona, F., Floris, G. et al. Upper limb movements in dementia with Lewy body: a quantitative analysis. Exp Brain Res 237, 2105–2110 (2019). https://doi.org/10.1007/s00221-019-05575-2
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DOI: https://doi.org/10.1007/s00221-019-05575-2