Experimental Brain Research

, Volume 233, Issue 8, pp 2421–2431 | Cite as

Inter-hemispheric desynchronization of the human MT+ during visually induced motion sickness

  • Jungo Miyazaki
  • Hiroki Yamamoto
  • Yoshikatsu Ichimura
  • Hiroyuki Yamashiro
  • Tomokazu Murase
  • Tetsuya Yamamoto
  • Masahiro Umeda
  • Toshihiro Higuchi
Research Article

Abstract

Visually induced motion sickness (VIMS) is triggered in susceptible individuals by stationary viewing of moving visual scenes. VIMS is often preceded by an illusion of self-motion (vection) and/or by inappropriate optokinetic nystagmus (OKN) responses associated with increased activity in the human motion-sensitive middle temporal area (MT+). Neuroimaging studies have reported predominant right hemispheric activation in MT+ during both vection and OKN, suggesting that VIMS may result from desynchronization of activity between left and right MT+ cortices. However, this possibility has not been directly tested. To this end, we presented VIMS-free and VIMS-inducing movies in that order while measuring the temporal correlations between corresponding left and right visual cortices (including MT+) using functional magnetic resonance imaging. The inter-hemispheric correlation was reduced significantly during the viewing of the VIMS-inducing movie compared to the control VIMS-free movie in the MT+ of subjects reporting VIMS, but not in insusceptible subjects. In contrast, there were no significant inter-hemispheric differences within VIMS-free or VIMS-inducing movie exposure for visual area V1, V2, V3, V3A or V7. Our findings provide the first evidence for an association between asynchronous bilateral MT+ activation and VIMS. Desynchronization of left and right MT+ regions may reflect hemispheric asymmetry in the activities of functional networks involved in eye movement control, vection perception and/or postural control.

Keywords

Human visual cortex Optokinetic nystagmus (OKN) Vection Functional magnetic resonance imaging (fMRI) Visual motion 

Supplementary material

Supplementary material 1 (MOV 7773 kb)

Supplementary material 2 (MOV 7906 kb)

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Supplementary material 5 (PDF 106 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Jungo Miyazaki
    • 1
  • Hiroki Yamamoto
    • 2
  • Yoshikatsu Ichimura
    • 1
  • Hiroyuki Yamashiro
    • 3
  • Tomokazu Murase
    • 4
  • Tetsuya Yamamoto
    • 5
  • Masahiro Umeda
    • 4
  • Toshihiro Higuchi
    • 6
  1. 1.Corporate R&DCanon Inc.TokyoJapan
  2. 2.Graduate School of Human and Environmental StudiesKyoto UniversityKyotoJapan
  3. 3.Department of Medical EngineeringAino UniversityOsakaJapan
  4. 4.Department of Medical InformaticsMeiji University of Integrative MedicineKyotoJapan
  5. 5.Graduate School of EngineeringKyoto UniversityKyotoJapan
  6. 6.Department of NeurosurgeryMeiji University of Integrative MedicineKyotoJapan

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