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The serotonin 5-HT7 receptors: two decades of research

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Abstract

Like most neurotransmitters, serotonin possesses a simple structure. However, the pharmacological consequences are more complex and diverse. Serotonin is involved in numerous functions in the human body including the control of appetite, sleep, memory and learning, temperature regulation, mood, behavior, cardiovascular function, muscle contraction, endocrine regulation, and depression. Low levels of serotonin may be associated with several disorders, namely increase in aggressive and angry behaviors, clinical depression, Parkinson’s disease, obsessive–compulsive disorder, eating disorders, migraine, irritable bowel syndrome, tinnitus, and bipolar disease. These effects are mediated via different serotonin (5-HT) receptors. In this review, we will focus on the last discovered member of this serotonin receptor family, the 5-HT7 receptor. This receptor belongs to the G protein-coupled receptor superfamily and was cloned two decades ago. Later, different splice variants were described but no major functional differences have been described so far. All 5-HT7 receptor variants are coupled to Gαs proteins and stimulate cAMP formation. Recently, several interacting proteins have been reported, which can influence receptor signaling and trafficking.

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Acknowledgments

This work was financially supported by Janssen Pharmaceutica N.V., Beerse, the IWT (Instituut voor de aanmoediging van innovatie door wetenschap en technologie in Vlaanderen) project no. 990173, FWO (Fonds voor wetenschappelijk onderzoek Vlaanderen; KVC has a postdoctoral FWO scholarship), the Norwegian Research Council and The Novo Nordisk Foundation.

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  1. Peter Vanhoenacker

    Present address: ActoGeniX, Technologiepark 4, Zwijnaarde, 9052, Ghent, Belgium

Authors and Affiliations

  1. Laboratory for Eukaryotic Gene Expression and Signal Transduction (LEGEST), Ghent University, Proeftuinstraat 86, 9000, Ghent, Belgium

    Evelien Gellynck, Karen Heyninck, Guy Haegeman, Peter Vanhoenacker & Kathleen Van Craenenbroeck

  2. Department of Pharmacology, Faculty of Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway

    Kjetil W. Andressen & Finn Olav Levy

  3. K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research, University of Oslo, Oslo, Norway

    Kjetil W. Andressen & Finn Olav Levy

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  1. Evelien Gellynck
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Correspondence to Kathleen Van Craenenbroeck.

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Gellynck, E., Heyninck, K., Andressen, K.W. et al. The serotonin 5-HT7 receptors: two decades of research. Exp Brain Res 230, 555–568 (2013). https://doi.org/10.1007/s00221-013-3694-y

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  • DOI: https://doi.org/10.1007/s00221-013-3694-y

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