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The vestibular system does not modulate fusimotor drive to muscle spindles in contracting leg muscles of seated subjects

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Abstract

We previously showed that sinusoidal galvanic vestibular stimulation (GVS) does not modulate the firing of spontaneously active muscle spindles in relaxed human leg muscles. However, given that there is little, if any, fusimotor drive to relaxed human muscles, we tested the hypothesis that vestibular modulation of muscle spindles becomes apparent during volitional contractions at levels that engage the fusimotor system. Unitary recordings were made from 28 muscle spindle afferents via tungsten microelectrodes inserted percutaneously into the common peroneal nerve of seated awake human subjects. Twenty-one of the spindle afferents were spontaneously active at rest and each increased its firing rate during a weak static contraction; seven were silent at rest and were recruited during the contraction. Sinusoidal bipolar binaural galvanic vestibular stimulation (±2 mA, 100 cycles) was applied to the mastoid processes at 0.8 Hz. This continuous stimulation produced a sustained illusion of “rocking in a boat” or “swinging in a hammock” but no entrainment of EMG. Despite these robust vestibular illusions, none of the fusimotor-driven muscle spindles exhibited phase-locked modulation of firing during sinusoidal GVS. We conclude that this dynamic vestibular input was not sufficient to modulate the firing of fusimotor neurones recruited during a voluntary steady-state contraction, arguing against a significant role of the vestibular system in adjusting the sensitivity of muscle spindles via fusimotor neurones.

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Acknowledgments

This study was supported by NSERC Post Doctoral Fellowship to LRB, and by the National Health and Medical Research Council of Australia (VGM). We express our gratitude to Dr. J. B. Fallon for technical and editorial contributions to this work.

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Authors and Affiliations

  1. Department of Human Health and Nutritional Services, University of Guelph, Guelph, Canada

    L. R. Bent

  2. Department of Aviation Medicine, Danish National Hospital, Dianalund, Denmark

    M. Sander

  3. School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia

    P. S. Bolton

  4. Neuroscience Research Institute, Sydney, Australia

    V. G. Macefield

  5. School of Medicine, University of Western Sydney, Locked Bag 1797, Penrith, Sydney, NSW, 2751, Australia

    V. G. Macefield

Authors
  1. L. R. Bent
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  2. M. Sander
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  3. P. S. Bolton
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  4. V. G. Macefield
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Correspondence to V. G. Macefield.

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Bent, L.R., Sander, M., Bolton, P.S. et al. The vestibular system does not modulate fusimotor drive to muscle spindles in contracting leg muscles of seated subjects. Exp Brain Res 227, 175–183 (2013). https://doi.org/10.1007/s00221-013-3497-1

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  • DOI: https://doi.org/10.1007/s00221-013-3497-1

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