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Reciprocal inhibition versus unloading response during stretch reflex in humans

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Abstract

Rotation of an upper limb joint produces excitatory stretch reflex peaks M1 and M2 in the stretched muscles and simultaneous decrease in electromyographic (EMG) activity in the shortened muscles. The objective of this study was to examine whether the decreased activity in the antagonists (rINHIB) is purely from unloading of the spindles or receives active inhibition involving inhibitory interneurons. If rINHIB is due only to unloading, then the termination of rINHIB should vary with the duration of perturbation used to elicit stretch reflex, namely shorter stretches should result in shorter values of decreased periods of EMG. To examine this question, rectangular pulses, ranging in duration from 25 to 150 ms, were used to stretch wrist flexors or extensors with a torque motor. These rectangular pulses resulted in joint rotations which peaked at times (T peak) ranging from approximately 75–160 ms. As shown by previous authors, when the duration of rotation was shortened, the magnitude of M1 did not change, while the magnitude of M2 decreased. However, termination time of rINHIB in the shortened muscles did not change with change in T peak, implying thereby that unloading of spindles of the antagonist muscles is not the only mechanism for the reduction in activity and that inhibitory reflex pathways most likely contribute. Possible sources of inhibition are discussed for the short- and long-latency inhibition.

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Acknowledgments

Authors thank Professor R Chua for his help with the manuscript. This work was supported by a grant from Natural Science and Engineering Research Council of Canada.

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  1. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada

    C. D. Manning, P. L. L. McDonald, C. D. Murnaghan & P. Bawa

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  1. C. D. Manning
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  3. C. D. Murnaghan
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  4. P. Bawa
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Correspondence to P. Bawa.

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Manning, C.D., McDonald, P.L.L., Murnaghan, C.D. et al. Reciprocal inhibition versus unloading response during stretch reflex in humans. Exp Brain Res 226, 33–43 (2013). https://doi.org/10.1007/s00221-013-3408-5

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  • DOI: https://doi.org/10.1007/s00221-013-3408-5

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