We examined the effects of hippocampal (HPC) damage on odour recognition memory, using a novel odour recognition task that was adapted from the more common novel object recognition task. Three separate experiments were conducted. In Experiment 1, we tested rats in novel odour recognition across different retention intervals (i.e. 15 min, 24 h, 1 week, 5 weeks). Given a single acquisition session, rats’ performance deteriorated after 24 h, but given multiple acquisition sessions (i.e. four sessions over 2 days), rats were able to perform well after retention intervals up to 5 weeks. In Experiment 2, we examined the possible anterograde amnesic effects of HPC damage on novel odour recognition, finding that pre-training damage to the entire HPC failed to cause amnesia for retention delays extending up to 5 weeks. In Experiment 3, we examined whether post-training HPC damage would cause retrograde amnesia, but failed to find any evidence of an impairment. The combined results suggest that the neural network supporting odour recognition is independent of the HPC.
Amnesia Lesion Novelty preference Odour Hippocampus Recognition Rat
This is a preview of subscription content, log in to check access.
We thank NSERC for funding this research as well as Dr. Deborah Saucier in providing useful comments on an earlier draft of this manuscript.
Clark RE, Zola SM, Squire LR (2000) Impaired recognition memory in rats after damage to the hippocampus. J Neurosci 20:8853–8860PubMedGoogle Scholar
Clark RE, West AN, Zola SM, Squire LR (2001) Rats with lesions of the hippocampus are impaired on the delayed nonmatching-to-sample task. Hippocampus 11:176–186PubMedCrossRefGoogle Scholar
Driscoll I, Howard SR, Prusky GT, Rudy JW, Sutherland RJ (2005) Seahorse wins all races: hippocampus participates in both linear and non-linear visual discrimination learning. Behav Brain Res 164:29–35PubMedCrossRefGoogle Scholar
Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data. Behav Brain Res 31:47–59PubMedCrossRefGoogle Scholar
Feinberg LM, Allen TA, Ly D, Fortin NJ (2012) Recognition memory for social and non-social odors: differential effects of neurotoxic lesions to the hippocampus and perirhinal cortex. Neurobiol Learn Mem 97:7–16. doi:10.1016/j.nlm.2011.08.008PubMedCrossRefGoogle Scholar
Frankland PW, Cestari V, Filipkowski RK, McDonald RJ, Silva AJ (1998) The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behav Neurosci 112:863–874PubMedCrossRefGoogle Scholar
Gaskin S, Tremblay A, Mumby DG (2003) Retrograde and anterograde object recognition in rats with hippocampal lesions. Hippocampus 13:962–969PubMedCrossRefGoogle Scholar
Glenn MJ, Lehmann H, Mumby DG, Woodside B (2005) Differential fos expression following aspiration, electrolytic, or excitotoxic lesions of the perirhinal cortex in rats. Behav Neurosci 119:806–813PubMedCrossRefGoogle Scholar
Maren S, Aharonov G, Fanselow MS (1997) Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav Brain Res 88:261–274PubMedCrossRefGoogle Scholar
Martin SJ, de Hoz L, Morris RG (2005) Retrograde amnesia: neither partial nor complete hippocampal lesions in rats result in preferential sparing of remote spatial memory, even after reminding. Neuropsychologia 43:609–624PubMedCrossRefGoogle Scholar
Mouton PR (2002) Principles and practices of unbiased stereology: an introduction for bioscientists. The Johns Hopkins University Press, BaltimoreGoogle Scholar
Mumby DG, Astur RS, Weisend MP, Sutherland RJ (1999) Retrograde amnesia and selective damage to the hippocampal formation: memory for places and object discriminations. Behav Brain Res 106:97–107PubMedCrossRefGoogle Scholar
Mumby DG, Gaskin S, Glenn MJ, Schramek TE, Lehmann H (2002) Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn Mem 9:49–57PubMedCrossRefGoogle Scholar