Abstract
In mild cognitive impairment (MCI), the corpus callosum is known to be affected structurally. We evaluated callosal function by interhemispheric inhibition (IHI) using transcranial magnetic stimulation (TMS) in MCI patients. We investigated 12 amnestic MCI patients and 16 healthy age-matched control subjects. The IHI was studied with a paired-pulse TMS technique. The conditioning TMS was given over the right primary motor cortex (M1) and the test TMS over the left M1. Motor evoked potentials were recorded from the relaxed first dorsal interosseous muscle. We also studied other motor cortical circuit functions; short-latency afferent inhibition (SAI), short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF). Both the amount of IHI and SAI were significantly reduced in MCI patients as compared with control subjects, whereas SICI or ICF did not differ between them. The degree of IHI significantly correlated with neither the mini-mental state examination score nor the degree of SAI. Our results suggest that transcallosal connection between bilateral M1 is primarily involved in MCI, regardless of SAI dysfunction.
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Acknowledgments
Part of this work was supported by the following: Research Project Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 22390181, No. 22590954, No. 20591019); the Research Committee on rTMS Treatment of Parkinson disease from the Ministry of Health, Labour and Welfare of Japan (H20-023); the Research Committee on Dystonia from the Ministry of Health, Labour and Welfare of Japan; the Research Committee on Intractable Pain from the Ministry of Health, Labour and Welfare of Japan; the Research Committee on Degenerative Ataxia from the Ministry of Health and Welfare of Japan; and the Global COE Program (Comprehensive Center of Education and Research for Chemical Biology of Diseases) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
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Tsutsumi, R., Hanajima, R., Hamada, M. et al. Reduced interhemispheric inhibition in mild cognitive impairment. Exp Brain Res 218, 21–26 (2012). https://doi.org/10.1007/s00221-011-2997-0
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DOI: https://doi.org/10.1007/s00221-011-2997-0