Experimental Brain Research

, 174:712 | Cite as

Responses of neurons in the lateral intraparietal area to central visual cues

  • Brian E. Russ
  • Amy M. Kim
  • Karilyn L. Abrahamsen
  • Ruwan Kiringoda
  • Yale E. Cohen
Research Article


Goal-directed behavior is characterized by flexible stimulus-action mappings. The lateral intraparietal area (area LIP) contains a representation of extra-personal space that is used to guide goal-directed behavior. To examine further how area LIP contributes to these flexible stimulus-action mappings, we recorded LIP activity while rhesus monkeys participated in two different cueing tasks. In the first task, the color of a central light indicated the location of a monkey’s saccadic endpoint in the absence of any other visual stimuli. In the second task, the color of a central light indicated which of two visual targets was the saccadic goal. In both tasks, LIP activity was modulated by these non-spatial cues. These observations further suggest a role for area LIP in mediating endogenous associations that link stimuli with actions.


Parietal cortex Rhesus macaque Attention Vision 


  1. Andersen RA (1987) Inferior parietal lobule function in spatial perception and visuomotor integration. In: Plum F, Mountcastle VM, Geirger SR (eds) The handbook of physiology, Sect. 1: the nervous system, vol. V. Higher functions of the brain, vol V. American Physiological Society, Bethesda, pp 483–518Google Scholar
  2. Andersen RA, Asanuma C, Essick G, Siegel RM (1990) Corticocortical connections of anatomically and physiologically defined subdivisions within the inferior parietal lobule. J Comp Neurol 296:65–113PubMedCrossRefGoogle Scholar
  3. Andersen RA, Buneo CA (2002) Intentional maps in posterior parietal cortex. Annu Rev Neurosci 25:189–220PubMedCrossRefGoogle Scholar
  4. Andersen RA, Snyder LH, Bradley DC, Xing J (1997) Multimodal representation of space in the posterior parietal cortex and its use in planning movements. Annu Rev Neurosci 20:303–330PubMedCrossRefGoogle Scholar
  5. Assad JA (2003) Neural coding of behavioral relevance in parietal cortex. Curr Opin Neurobiol 13:194–197PubMedCrossRefGoogle Scholar
  6. Barash S, Bracewell RM, Fogassi L, Gnadt JW, Andersen RA (1991a) Saccade-related activity in the lateral intraparietal area. I. Temporal properties; comparison with area 7a. J Neurophysiol 66:1095–1108Google Scholar
  7. Barash S, Bracewell RM, Fogassi L, Gnadt JW, Andersen RA (1991b) Saccade-related activity in the lateral intraparietal area. II. Spatial properties. J Neurophysiol 66:1109–1124Google Scholar
  8. Becker W, Fuchs AF (1969) Further properties of the human saccadic system: eye movements and correction saccades with and without visual fixation points. Vis Res 9:1247–1258PubMedCrossRefGoogle Scholar
  9. Bisley JW, Goldberg ME (2003) Neuronal activity in the lateral intraparietal area and spatial attention. Science 299:81–86PubMedCrossRefGoogle Scholar
  10. Bushnell MC, Goldberg ME, Robinson DL (1981) Behavioral enhancement of visual responses in monkey cerebral cortex. I. Modulation in posterior parietal cortex related to selective visual attention. J Neurophysiol 46:755–772PubMedGoogle Scholar
  11. Calton JL, Dickinson AR, Snyder LH (2002) Non-spatial, motor-specific activation in posterior parietal cortex. Nat Neurosci 5:580–588PubMedCrossRefGoogle Scholar
  12. Cohen YE, Andersen RA (2002) A common reference frame for movement plans in the posterior parietal cortex. Nat Rev Neurosci 3:553–562PubMedCrossRefGoogle Scholar
  13. Cohen YE, Batista AP, Andersen RA (2002) Comparison of neural activity preceding reaches to auditory and visual stimuli in the parietal reach region. Neuroreport 13:891–894PubMedCrossRefGoogle Scholar
  14. Cohen YE, Cohen IS, Gifford III GW (2004a) Modulation of LIP activity by predictive auditory and visual cues. Cereb Cortex 14:1287–1301CrossRefGoogle Scholar
  15. Cohen YE, Russ BE, Gifford III GW, Kiringoda R, MacLean KA (2004b) Selectivity for the spatial and nonspatial attributes of auditory stimuli in the ventrolateral prefrontal cortex. J Neurosci 24:11307–11316CrossRefGoogle Scholar
  16. Cover TM, Thomas JA (1991) Elements of information theory. Wiley, New YorkGoogle Scholar
  17. Critchley M (1966) The parietal lobes. Hafner Publishing Co., New YorkGoogle Scholar
  18. Dickinson AR, Calton JL, Snyder LH (2003) Nonspatial saccade-specific activation in area LIP of monkey parietal cortex. J Neurophysiol 90:2460–2464PubMedCrossRefGoogle Scholar
  19. Egeth HE, Yantis S (1997) Visual attention: control, representation, and time course. Annu Rev Psychol 48:269–297PubMedCrossRefGoogle Scholar
  20. Gifford III GW, Cohen YE (2004) The effect of a central fixation light on auditory spatial responses in area LIP. J Neurophysiol 91:2929–2933PubMedCrossRefGoogle Scholar
  21. Gifford III GW, Cohen YE (2005) Spatial and non-spatial auditory processing in the lateral intraparietal area. Exp Brain Res 162:509–512PubMedCrossRefGoogle Scholar
  22. Gnadt JW, Andersen RA (1988) Memory related motor planning activity in posterior parietal cortex of macaque. Exp Brain Res 70:216–220PubMedGoogle Scholar
  23. Goldberg ME, Bisley J, Powell KD, Gottlieb J, Kusunoki M (2002) The role of the lateral intraparietal area of the monkey in the generation of saccades and visuospatial attention. Ann N Y Acad Sci 956:205–215PubMedCrossRefGoogle Scholar
  24. Gottlieb J, Goldberg ME (1999) Activity of neurons in the lateral intraparietal area of the monkey during an antisaccade task. Nat Neurosci 2:906–912PubMedCrossRefGoogle Scholar
  25. Gottlieb JP, Kusunoki M, Goldberg ME (1998) The representation of visual salience in monkey parietal cortex. Nature 391:481–484PubMedCrossRefGoogle Scholar
  26. Groh JM, Trause AS, Underhill AM, Clark KR, Inati S (2001) Eye position influences auditory responses in primate inferior colliculus. Neuron 29:509–518PubMedCrossRefGoogle Scholar
  27. Grunewald A, Linden JF, Andersen RA (1999) Responses to auditory stimuli in macaque lateral intraparietal area. I. Effects of training. J Neurophysiol 82:330–342PubMedGoogle Scholar
  28. Hyvärinen J (1982) Posterior parietal lobule of the primate brain. Physiol Rev 62:1060–1129PubMedGoogle Scholar
  29. Judge SJ, Richmond BJ, Chu FC (1980) Implantation of magnetic search coils for measurement of eye position: an improved method. Vis Res 20:535–538PubMedCrossRefGoogle Scholar
  30. Kusunoki M, Gottlieb J, Goldberg ME (2000a) The lateral intraparietal area as a salience map: the representation of abrupt onset, stimulus motion, and task relevance. Vis Res 40:1459–1468CrossRefGoogle Scholar
  31. Kusunoki M, Gottlieb J, Goldberg ME (2000b) The lateral intraparietal area as a salience map: the representation of abrupt onset, stimulus motion, and task relevance. Vis Res 40:1459–1468CrossRefGoogle Scholar
  32. LaBerge D (1995) Attentional processing: the brain’s art of mindfulness. Harvard University Press, CambridgeGoogle Scholar
  33. Lewis JW, Van Essen DC (2000) Corticocortical connections of visual, sensorimotor, and multimodal processing areas in the parietal lobe of the macaque monkey. J Comp Neurol 428:112–137PubMedCrossRefGoogle Scholar
  34. Linden JF, Grunewald A, Andersen RA (1999) Responses to auditory stimuli in macaque lateral intraparietal area. II. Behavioral modulation. J Neurophysiol 82:343–358PubMedGoogle Scholar
  35. Mountcastle VB, Lynch JC, Georgopoulos A, Sakata H, Acuna C (1975) Posterior parietal association cortex of the monkey: command functions for operations within extrapersonal space. J Neurophysiol 38:871–908PubMedGoogle Scholar
  36. Nieder A, Miller EK (2004) A parieto-frontal network for visual numerical information in the monkey. Proc Natl Acad Sci USA 101:7457–7462PubMedCrossRefGoogle Scholar
  37. Panzeri S, Treves A (1996) Analytical estimates of limited sampling biases in different information measures. Network 7:87–107CrossRefGoogle Scholar
  38. Platt ML, Glimcher PW (1997) Responses of intraparietal neurons to saccadic targets and visual distractors. J Neurophysiol 78:1574–1589PubMedGoogle Scholar
  39. Platt ML, Glimcher PW (1998) Response fields of intraparietal neurons quantified with multiple saccadic targets. Exp Brain Res 121:65–75PubMedCrossRefGoogle Scholar
  40. Platt ML, Glimcher PW (1999) Neural correlates of decision variables in parietal cortex. Nature 400:233–238PubMedCrossRefGoogle Scholar
  41. Posner MI (1980) Orienting of attention. Q J Exp Psychol 32:3–25PubMedGoogle Scholar
  42. Powell KD, Goldberg ME (2000) Response of neurons in the lateral intraparietal area to a distractor flashed during the delay period of a memory-guided saccade. J Neurophysiol 84:301–310PubMedGoogle Scholar
  43. Robinson DL, Bowman EM, Kertzman C (1995) Covert orienting of attention in macaques. II. Contributions of parietal cortex. J Neurophysiol 74:698–712PubMedGoogle Scholar
  44. Sawamura H, Shima K, Tanji J (2002) Numerical representation for action in the parietal cortex of the monkey. Nature 415:918–922PubMedCrossRefGoogle Scholar
  45. Sereno AB, Maunsell JH (1998) Shape selectivity in primate lateral intraparietal cortex. Nature 395:500–503PubMedCrossRefGoogle Scholar
  46. Shadlen MN, Newsome WT (1996) Motion perception: seeing and deciding. Proc Natl Acad Sci USA 93:628–633PubMedCrossRefGoogle Scholar
  47. Shadlen MN, Newsome WT (2001) Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey. J Neurophysiol 86:1916–1936PubMedGoogle Scholar
  48. Shannon CE (1948a) A mathematical theory of communication. Bell Syst Techn J 27:379–423Google Scholar
  49. Shannon CE (1948b) A mathematical theory of communication. Bell Syst Techn J 27:623–656Google Scholar
  50. Snyder LH (2000) Coordinate transformations for eye and arm movements in the brain. Curr Opin Neurobiol 10:747–754PubMedCrossRefGoogle Scholar
  51. Snyder LH, Batista AP, Andersen RA (1997) Coding of intention in the posterior parietal cortex. Nature 386:167–170PubMedCrossRefGoogle Scholar
  52. Snyder LH, Batista AP, Andersen RA (2000) Intention-related activity in the posterior parietal cortex: a review. Vis Res 40:1433–1441PubMedCrossRefGoogle Scholar
  53. Snyder LH, Calton JL, Dickinson AR, Lawrence BM (2002) Eye-hand coordination: saccades are faster when accompanied by a coordinated arm movement. J Neurophysiol 87:2279–2286PubMedGoogle Scholar
  54. Stoet G, Snyder LH (2004) Single neurons in posterior parietal cortex of monkeys encode cognitive set. Neuron 42:1003–1012PubMedCrossRefGoogle Scholar
  55. Sugrue LP, Corrado GS, Newsome WT (2004) Matching behavior and the representation of value in the parietal cortex. Science 304:1782–1787PubMedCrossRefGoogle Scholar
  56. Thompson RF, Mayers KS, Robertson RT, Patterson CJ (1970) Number coding in association cortex of the cat. Science 168:271–273PubMedGoogle Scholar
  57. Toth LJ, Assad JA (2002) Dynamic coding of behaviourally relevant stimuli in parietal cortex. Nature 415:165–168PubMedCrossRefGoogle Scholar
  58. Zambarbieri D, Beltrami G, Versino M (1995) Saccade latency toward auditory targets depends on the relative position of the sound source with respect to the eyes. Vis Res 35:3305–3312PubMedCrossRefGoogle Scholar
  59. Zambarbieri D, Schmid R, Magenes G, Prablanc C (1982) Saccadic responses evoked by presentation of visual and auditory targets. Exp Brain Res 47:417–427PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Brian E. Russ
    • 1
  • Amy M. Kim
    • 1
  • Karilyn L. Abrahamsen
    • 1
  • Ruwan Kiringoda
    • 1
  • Yale E. Cohen
    • 1
  1. 1.Department of Psychological and Brain Sciences and Center for Cognitive NeuroscienceDartmouth CollegeHanoverUSA

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