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Experimental Brain Research

, Volume 155, Issue 2, pp 204–210 | Cite as

Influence of working memory on patterns of motor related cortico-cortical coupling

  • Deborah J. SerrienEmail author
  • Alek H. Pogosyan
  • Peter Brown
Research Article

Abstract

Working memory is implicated in various higher-order cognitive operations. We hypothesized that the availability of a temporal representation in working memory would limit the extent of cortico-cortical coupling necessary to undertake a self-paced rhythmic movement. To this end we examined modulations in cortico-cortical interactions as determined by EEG coherence during a delay interval and subsequent movement reproduction. Right hand movement was initially paced by a metronome beat every 0.9 s, followed by a delay interval, after which hand movement was repeated in an unpaced manner. Movement reproduction after a long (22.5 s, corresponding to 25 movement cycles) compared to a short (5.4 s, corresponding to 6 movement cycles) delay interval was associated with an increased degree of functional coupling in the beta frequency band (12–30 Hz) of the left (movement-driving) hemisphere (F3-FC3, F3-C3 and F3-P3 connections) as well as mesial regions (FCz-FC3, FCz-C3 and Cz-FC3 connections) even though overall behavioral characteristics were not influenced. In addition, analysis of the EEG coherence in the delay period revealed a bilateral frontal network (F3-F4, F3-FC4, F4-FC3 and FC3-FC4 connections). Activity in the latter tended to be synchronized in the theta band (4–8 Hz) and was significantly less strong at 22.5 s than 5.4 s. These data suggest that working memory may be partly subserved by synchronization in a bilateral frontal network and may provide an intrinsic contextual influence that shapes the pattern of cortico-cortical interaction during a given task.

Keywords

EEG Task-related coherence Functional coupling Working memory 

Notes

Acknowledgements

The research was supported by the Medical Research Council of Great Britain and GlaxoSmithKline.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Deborah J. Serrien
    • 1
    Email author
  • Alek H. Pogosyan
    • 1
  • Peter Brown
    • 1
  1. 1.Sobell Department of Motor Neuroscience and Movement Disorders (Box 146)Institute of NeurologyLondonUK

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