Visually guided grasping produces fMRI activation in dorsal but not ventral stream brain areas
- 2.3k Downloads
Although both reaching and grasping require transporting the hand to the object location, only grasping also requires processing of object shape, size and orientation to preshape the hand. Behavioural and neuropsychological evidence suggests that the object processing required for grasping relies on different neural substrates from those mediating object recognition. Specifically, whereas object recognition is believed to rely on structures in the ventral (occipitotemporal) stream, object grasping appears to rely on structures in the dorsal (occipitoparietal) stream. We used functional magnetic resonance imaging (fMRI) to determine whether grasping (compared to reaching) produced activation in dorsal areas, ventral areas, or both. We found greater activity for grasping than reaching in several regions, including anterior intraparietal (AIP) cortex. We also performed a standard object perception localizer (comparing intact vs. scrambled 2D object images) in the same subjects to identify the lateral occipital complex (LOC), a ventral stream area believed to play a critical role in object recognition. Although LOC was activated by the objects presented on both grasping and reaching trials, there was no greater activity for grasping compared to reaching. These results suggest that dorsal areas, including AIP, but not ventral areas such as LOC, play a fundamental role in computing object properties during grasping.
KeywordsfMRI Grasping Reaching Visuomotor control Parietal cortex
These projects would not have been possible without the engineering skills needed to design the apparatus. We are especially grateful to Dave Woytowich and Bob Stuart at UWO Engineering Machine Shops for designing and building the grasparatus, to Dan Pulham for wiring the electronics, to Leopold van Cleeff and Derek Quinlan for developing other hardware, and to Raynald Comtois for programming the input/output card. Philip Servos provided the air compressor and solenoids and assistance with their use. Zoe Kourtzi generously provided the object stimuli and Matlab code to present them. These experiments were supported by grants from the McDonnell-Pew Program in Cognitive Neuroscience (to JCC), the Canadian Institutes of Health Research (Operating Grant to MAG and NSERC/CIHR Multi-User Maintenance grant to RSM and colleagues), and the Canada Research Chairs Program (to MAG and RSM).
- Connolly J, Andersen RA, Goodale MA (2003) fMRI evidence for a 'parietal reach region' in human brain. Exp Brain Res DOI 10.1007/s00221-003-1587-1Google Scholar
- Culham J (in press) Human brain imaging reveals a parietal area specialized for grasping. In: Kanwisher N, Duncan J (eds) Attention and performance XX: functional neuroimaging of human cognition. Oxford University Press, OxfordGoogle Scholar
- Culham JC, DeSouza JFX, Woodward S, Kourtzi Z, Gati JS, Menon RS, Goodale MA (2001) Visually-guided grasping produces fMRI activation in dorsal but not ventral stream brain areas. J Vision 1:194Google Scholar
- James TW, Culham JC, Humphrey GK, Milner AD, Goodale MA (in press) fMRI evidence for a neurological dissociation between perceiving objects and grasping them. BrainGoogle Scholar
- Jeannerod M (1981) Intersegmental coordination during reaching at natural visual objects. In: Long J, Baddeley A (eds) Attention and performance IX. Erlbaum, Hillsdale NJ, pp 153–168Google Scholar
- Lawrence BM, Snyder LH (2002) Effector specific and non-specific activity in frontal eye fields. Soc Neurosci Abstr:622.628Google Scholar
- Sakata H, Taira M, Mine S, Murata A (1992) Hand-movement-related neurons of the posterior parietal cortex of the monkey: their role in the visual guidance of hand movements. In: Caminiti R, Johnson PB, Burnod Y (eds) Control of arm movement in space: neurophysiological and computational approaches. Springer, Heidelberg, pp 185–198Google Scholar
- Steeves JKE, Humphrey GK, Culham JC, Menon RS, Milner AD, Goodale MA (submitted) Behavioral and neuroimaging evidence for a contribution of color information to scene recognition in a patient with impaired form recognitionGoogle Scholar
- Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Thieme Medical Publishers, New YorkGoogle Scholar