Skip to main content
SpringerLink
Log in

Cancellation of visuoparietal lesion-induced spatial neglect

  • Research Note
  • Published:
Experimental Brain Research Aims and scope Submit manuscript

Abstract

In humans lesions of right visuoparietal cortex induce a neglect of the contralesional visual field that is characterized in its mild form by inattentiveness to objects and events and, in its more severe form, by a condition that has many features that are indistinguishable from blindness. Here we show that spatial neglect can be induced in cats by lesions of posterior and inferior visuoparietal cortex, and that the lesion-induced neglect can be cancelled by cooling deactivation of the same region in the opposite hemisphere.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1A–E.

Similar content being viewed by others

References

  • Cowey A, Walsh V (2001) Tickling the brain: studying visual sensation, perception and cognition by transcranial magnetic stimulation. Prog Brain Res 134:411–425

    CAS  PubMed  Google Scholar 

  • Hardy SC, Stein BE (1988) Small lateral suprasylvian cortex lesions produce visual neglect and decreased visual activity in the superior colliculus. J Comp Neurol 273:527–542

    CAS  PubMed  Google Scholar 

  • Hilgetag CC, Kötter R, Young MP (1999) Inter-hemispheric competition of sub-cortical structures is a crucial mechanism in paradoxical lesion effects and spatial neglect. Prog Brain Res 121:121–141

    CAS  PubMed  Google Scholar 

  • Kapur N (1996) Paradoxical functional facilitation in brain-behaviour research. A critical review. Brain 119:1775–1790

    PubMed  Google Scholar 

  • Lomber SG (2001) Behavioral cartography of visual functions in cat parietal cortex: areal and laminar dissociations. Prog Brain Res 134:265–284

    CAS  PubMed  Google Scholar 

  • Lomber SG, Payne BR (1996) Removal of two halves restores the whole: reversal of visual hemineglect during bilateral cortical or collicular inactivation in the cat. Vis Neurosci 13:1143–1156

    CAS  PubMed  Google Scholar 

  • Lomber SG, Payne BR, Cornwell P, Long KD (1996) Perceptual and cognitive visual functions of parietal and temporal cortices in the cat. Cereb Cortex 6:673–695

    CAS  PubMed  Google Scholar 

  • Lomber SG, Payne BR, Horel JA (1999) The cryoloop: an adaptable reversible cooling deactivation method for behavioral or electrophysiological assessment of neural function. J Neurosci Methods 86:179–194

    Article  CAS  PubMed  Google Scholar 

  • Lynch JC, McLaren JW (1989) Deficits of visual attention and saccadic eye movements after lesions of parietooccipital cortex in monkeys. J Neurophysiol 61:74–90

    CAS  PubMed  Google Scholar 

  • Oliveri M, Rossini PM, Traversa R, Cicinelli P, Filippi MM, Pasqualetti P, Tomaiuolo F, Caltagirone C (1999) Left frontal transcranial magnetic stimulation reduces contralesional extinction in patients with unilateral right brain damage. Brain 122:1731–1739

    PubMed  Google Scholar 

  • Oliveri M, Bisiach E, Brighina F, Piazza A, La Bua V, Buffa D, Fierro B (2001) rTMS of the unaffected hemisphere transiently reduces contralesional visuospatial hemineglect. Neurology 57:1338–1340

    CAS  PubMed  Google Scholar 

  • Pascual-Leone A, Davey N, Rothwell J, Wasserman E, Puri BK (2002) Handbook of transcranial magnetic stimulation. Oxford University Press, Oxford

  • Payne BR, Lomber SG (1999) A method to assess the functional impact of cerebral connections on target populations of neurons. J Neurosci Methods 86:195–208

    Article  CAS  PubMed  Google Scholar 

  • Payne BR, Lomber SG (2002) The use of cooling deactivation to reveal the neural basis of lesion-induced plasticity in the developing and mature brain. In: Lomber SG, Galuske RAW (eds) Virtual lesions. Oxford University Press, Oxford, pp 163–188

  • Payne BR, Lomber SG, Geeraerts S, Van der Gucht E, Vandenbussche E (1996) Reversible visual hemineglect. Proc Natl Acad Sci U S A 93:290–294

    Article  CAS  PubMed  Google Scholar 

  • Sherman SM (1977) The effect of superior colliculus lesions upon the visual fields of cats with cortical ablations. J Comp Neurol 172:211–229

    CAS  PubMed  Google Scholar 

  • Sprague JM (1966) Interaction of cortex and superior colliculus in mediation of visually guided behavior in the cat. Science 153:1544–1547

    CAS  PubMed  Google Scholar 

  • Sprague JM (1996) Neural mechanisms of visual orienting responses. Prog Brain Res 112:1–15

    CAS  PubMed  Google Scholar 

  • Taub E, Uswatte G, Elbert T (2002) New treatments in neurorehabilitation founded on basic research. Nat Rev Neurosci 3:228–236

    Article  CAS  PubMed  Google Scholar 

  • Vanduffel W, Payne BR, Lomber SG, Orban GA (1997) Functional impact of cerebral connections. Proc Natl Acad Sci U S A 94:7617–7620

    Article  CAS  PubMed  Google Scholar 

  • Vuilleumier P, Hester D, Assal G, Regli F (1996) Unilateral spatial neglect recovery after sequential strokes. Neurology 46:184–189

    CAS  PubMed  Google Scholar 

  • Watson RT, Valenstein E, Day A, Heilman KM (1994) Posterior neocortical systems subserving awareness and neglect. Neglect associated with superior temporal sulcus but not area 7 lesions. Arch Neurol 51:1014–1021

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The work was supported by the National Institute for Neurological Disease and Stroke.

Author information

Authors and Affiliations

  1. Cerebral Dynamics, Department of Anatomy and Neurobiology, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA

    Bertram R. Payne

  2. Cerebral Systems, School of Behavioral and Brain Sciences, University of Texas at Dallas, PO Box 830688, GR41, Richardson, TX 75083-0688, USA

    Stephen G. Lomber

  3. Cerebral Dynamics, Department of Anatomy and Neurobiology, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA

    Richard J. Rushmore

  4. Department of Neurology, Beth Israel-Deaconness Med. Ctr, Kirstein Hall, 330 Brookline Avenue, KS 454, Boston, MA 02215, USA

    Alvaro Pascual-Leone

Authors
  1. Bertram R. Payne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen G. Lomber
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richard J. Rushmore
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alvaro Pascual-Leone
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bertram R. Payne.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Payne, B.R., Lomber, S.G., Rushmore, R.J. et al. Cancellation of visuoparietal lesion-induced spatial neglect. Exp Brain Res 150, 395–398 (2003). https://doi.org/10.1007/s00221-003-1473-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00221-003-1473-x

Keywords

Search

Navigation